Title:
METHOD FOR PRODUCING FLUORESCENT MAGNETIC NANOPARTICLES, AND FLUORESCENT MAGNETIC NANOPARTICLES PRODUCED THROUGH SAME
Document Type and Number:
WIPO Patent Application WO/2023/149748
Kind Code:
A1
Abstract:
A method for producing fluorescent magnetic nanoparticles is provided. Fluorescent magnetic nanoparticles, according to one embodiment of the present invention, are implemented comprising the steps of: (1) preparing a magnetic body as a core part; and (2) forming a first silica layer by treating a first silica forming component to surround the core part, and then forming a fluorescent shell part containing a silica layer and a fluorescent material doped in the silica layer by treating, on the first silica layer, a fluorescent material, which is a lanthanide complex, and a second silica-forming component. According to this, the produced fluorescent magnetic nanoparticles are very uniform and prevent agglomeration, can express high PL intensity and quantum yield, and have excellent durability. In addition, since the fluorescent magnetic nanoparticles can improve flowability, the range of applications thereof can be further expanded in various diagnostic and detection fields, and can be widely applied to various fields of diagnosis and detection, such as in a highly sensitive in vitro diagnostic kit and a fluorescent nanoprobe for biomolecular imaging diagnosis which is useful for detecting a target substance.
Inventors:
KIM SUNG-IL (KR)
LEE JAEBEOM (KR)
HWANG DAJEONG (KR)
NGUYEN HUU-QUANG (KR)
LEE JAEBEOM (KR)
HWANG DAJEONG (KR)
NGUYEN HUU-QUANG (KR)
Application Number:
PCT/KR2023/001583
Publication Date:
August 10, 2023
Filing Date:
February 03, 2023
Export Citation:
Assignee:
AMOLIFESCIENCE CO LTD (KR)
IAC IN NAT UNIV CHUNGNAM (KR)
IAC IN NAT UNIV CHUNGNAM (KR)
International Classes:
C09K11/06; C01G49/08; C09K11/02; G01N33/543; H01F1/01; B82Y15/00; B82Y40/00
Foreign References:
| US20100276672A1 | 2010-11-04 |
Other References:
LI XIAOLEI, WANG WEI, LI QIANLI, LIN HAN, XU YUE, ZHUANG LIN: "Design of Fe3O4@SiO2@mSiO2-organosilane carbon dots nanoparticles: Synthesis and fluorescence red-shift properties with concentration dependence", MATERIALS & DESIGN, ELSEVIER, AMSTERDAM, NL, vol. 151, 1 August 2018 (2018-08-01), AMSTERDAM, NL , pages 89 - 101, XP093082910, ISSN: 0264-1275, DOI: 10.1016/j.matdes.2018.04.051
WU, J. YE, Z. WANG, G. YUAN, J.: "Multifunctional nanoparticles possessing magnetic, long-lived fluorescence and bio-affinity properties for time-resolved fluorescence cell imaging", TALANTA, ELSEVIER, AMSTERDAM, NL, vol. 72, no. 5, 4 July 2007 (2007-07-04), NL , pages 1693 - 1697, XP022141704, ISSN: 0039-9140
GODERSKI SZYMON, KANNO SHUHEI, YOSHIHARA KOUSHI, KOMIYA HIROAKI, GOTO KENTA, TANAKA TAKESHI, KAWAGUCHI SHOGO, ISHII AYUMI, SHIMOYA: "Lanthanide Luminescence Enhancement of Core–Shell Magnetite–SiO 2 Nanoparticles Covered with Chain-Structured Helical Eu/Tb Complexes", ACS OMEGA, ACS PUBLICATIONS, US, vol. 5, no. 51, 29 December 2020 (2020-12-29), US , pages 32930 - 32938, XP093082911, ISSN: 2470-1343, DOI: 10.1021/acsomega.0c03746
SONMEZ MARIA, GEORGESCU MIHAI, ALEXANDRESCU LAURENTIA, GURAU DANA, FICAI ANTON, FICAI DENISA, ANDRONESCU ECATERINA: "Synthesis and Applications of Fe 3 O 4 /SiO 2 Core-Shell Materials", CURRENT PHARMACEUTICAL DESIGN, vol. 21, no. 37, 1 January 2015 (2015-01-01), pages 5324 - 5335, XP093082913, DOI: 10.2174/1381612821666150917094031
CHENG JIANJUN, TAN GUANGHUI, LI WENTING, LI JINGHUA, WANG ZHIQIANG, JIN YINGXUE: "Preparation, characterization and in vitro photodynamic therapy of a pyropheophorbide-a-conjugated Fe 3 O 4 multifunctional magnetofluorescence photosensitizer", RSC ADVANCES, vol. 6, no. 44, 1 January 2016 (2016-01-01), pages 37610 - 37620, XP093082915, DOI: 10.1039/C6RA03128E
WU, J. YE, Z. WANG, G. YUAN, J.: "Multifunctional nanoparticles possessing magnetic, long-lived fluorescence and bio-affinity properties for time-resolved fluorescence cell imaging", TALANTA, ELSEVIER, AMSTERDAM, NL, vol. 72, no. 5, 4 July 2007 (2007-07-04), NL , pages 1693 - 1697, XP022141704, ISSN: 0039-9140
GODERSKI SZYMON, KANNO SHUHEI, YOSHIHARA KOUSHI, KOMIYA HIROAKI, GOTO KENTA, TANAKA TAKESHI, KAWAGUCHI SHOGO, ISHII AYUMI, SHIMOYA: "Lanthanide Luminescence Enhancement of Core–Shell Magnetite–SiO 2 Nanoparticles Covered with Chain-Structured Helical Eu/Tb Complexes", ACS OMEGA, ACS PUBLICATIONS, US, vol. 5, no. 51, 29 December 2020 (2020-12-29), US , pages 32930 - 32938, XP093082911, ISSN: 2470-1343, DOI: 10.1021/acsomega.0c03746
SONMEZ MARIA, GEORGESCU MIHAI, ALEXANDRESCU LAURENTIA, GURAU DANA, FICAI ANTON, FICAI DENISA, ANDRONESCU ECATERINA: "Synthesis and Applications of Fe 3 O 4 /SiO 2 Core-Shell Materials", CURRENT PHARMACEUTICAL DESIGN, vol. 21, no. 37, 1 January 2015 (2015-01-01), pages 5324 - 5335, XP093082913, DOI: 10.2174/1381612821666150917094031
CHENG JIANJUN, TAN GUANGHUI, LI WENTING, LI JINGHUA, WANG ZHIQIANG, JIN YINGXUE: "Preparation, characterization and in vitro photodynamic therapy of a pyropheophorbide-a-conjugated Fe 3 O 4 multifunctional magnetofluorescence photosensitizer", RSC ADVANCES, vol. 6, no. 44, 1 January 2016 (2016-01-01), pages 37610 - 37620, XP093082915, DOI: 10.1039/C6RA03128E
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
Download PDF: