Title:
METHOD OF PRODUCING AN IMMUNOLIGAN D/PAYLO AD CONJUGATE BY MEANS OF A SEQUENCE-SPECIFIC TRANSPEPTIDASE ENZYME
Document Type and Number:
WIPO Patent Application WO/2014/140317
Kind Code:
A3
Abstract:
The present invention relates to a method of producing an immunoligand/payload conjugate, which method encompasses conjugating a payload to an immunoligand by means of a sequence-specific transpeptidase, or a catalytic domain thereof.
Inventors:
GRAWUNDER ULF (CH)
BEERLI ROGER RENZO (CH)
BEERLI ROGER RENZO (CH)
Application Number:
PCT/EP2014/055173
Publication Date:
December 24, 2014
Filing Date:
March 14, 2014
Export Citation:
Assignee:
NBE THERAPEUTICS LLC (CH)
International Classes:
A61K47/48; C07K1/107; C07K16/18
Domestic Patent References:
| WO2007108013A2 | 2007-09-27 | |||
| WO2011133704A2 | 2011-10-27 | |||
| WO2012142659A1 | 2012-10-26 | |||
| WO2013022808A2 | 2013-02-14 | |||
| WO2009132455A1 | 2009-11-05 | |||
| WO2007076974A2 | 2007-07-12 |
Foreign References:
| US20100055761A1 | 2010-03-04 | |||
| US20110321183A1 | 2011-12-29 | |||
| US20040077842A1 | 2004-04-22 |
Other References:
SWEE LEE KIM ET AL: "Sortase-mediated modification of alpha DEC205 affords optimization of antigen presentation and immunization against a set of viral epitopes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 110, no. 4, January 2013 (2013-01-01), pages 1428 - 1433, XP002702777, ISSN: 0027-8424
TSUKIJI SHINYA ET AL: "Sortase-Mediated Ligation: A Gift from Gram-Positive Bacteria to Protein Engineering", vol. 10, no. 5, 23 March 2009 (2009-03-23), pages 787 - 798, XP002686613, ISSN: 1439-4227, Retrieved from the Internet [retrieved on 20090206], DOI: 10.1002/CBIC.200800724
TA H T ET AL: "Enzymatic Single-Chain Antibody Tagging A Universal Approach to Targeted Molecular Imaging and Cell Homing in Cardiovascular Disease", CIRCULATION RESEARCH, vol. 109, no. 4, August 2011 (2011-08-01), pages 365, XP002725099, ISSN: 0009-7330
MADEJ MARIUSZ P ET AL: "Engineering of an anti-epidermal growth factor receptor antibody to single chain format and labeling by Sortase A-mediated protein ligation.", BIOTECHNOLOGY AND BIOENGINEERING JUN 2012, vol. 109, no. 6, June 2012 (2012-06-01), pages 1461 - 1470, XP002725100, ISSN: 1097-0290
BAER SAMUEL ET AL: "Comparison of alternative nucleophiles for Sortase A-mediated bioconjugation and application in neuronal cell labelling.", ORGANIC & BIOMOLECULAR CHEMISTRY 7 MAY 2014, vol. 12, no. 17, 7 May 2014 (2014-05-07), pages 2675 - 2685, XP002725101, ISSN: 1477-0539
MCCLUSKEY A J ET AL: "Receptor-directed chimeric toxins created by sortase-mediated protein fusion", MOLECULAR CANCER THERAPEUTICS 2013 AMERICAN ASSOCIATION FOR CANCER RESEARCH INC. USA, vol. 12, no. 10, October 2013 (2013-10-01), pages 2273 - 2281, XP002725102, ISSN: 1535-7163
VOLKMANN GERRIT ET AL: "Protein C-Terminal Labeling and Biotinylation Using Synthetic Peptide and Split-Intein", PLOS ONE, vol. 4, no. 12, E8381, 21 December 2009 (2009-12-21), pages 1 - 12, XP002730633, ISSN: 1932-6203
SONG H ET AL: "Protein Trans-Splicing of an Atypical Split Intein Showing Structural Flexibility and Cross-Reactivity", PLOS ONE 20120914 PUBLIC LIBRARY OF SCIENCE USA, vol. 7, no. 9, 14 September 2012 (2012-09-14), XP002730634, ISSN: 1932-6203
TSUKIJI SHINYA ET AL: "Sortase-Mediated Ligation: A Gift from Gram-Positive Bacteria to Protein Engineering", vol. 10, no. 5, 23 March 2009 (2009-03-23), pages 787 - 798, XP002686613, ISSN: 1439-4227, Retrieved from the Internet
TA H T ET AL: "Enzymatic Single-Chain Antibody Tagging A Universal Approach to Targeted Molecular Imaging and Cell Homing in Cardiovascular Disease", CIRCULATION RESEARCH, vol. 109, no. 4, August 2011 (2011-08-01), pages 365, XP002725099, ISSN: 0009-7330
MADEJ MARIUSZ P ET AL: "Engineering of an anti-epidermal growth factor receptor antibody to single chain format and labeling by Sortase A-mediated protein ligation.", BIOTECHNOLOGY AND BIOENGINEERING JUN 2012, vol. 109, no. 6, June 2012 (2012-06-01), pages 1461 - 1470, XP002725100, ISSN: 1097-0290
BAER SAMUEL ET AL: "Comparison of alternative nucleophiles for Sortase A-mediated bioconjugation and application in neuronal cell labelling.", ORGANIC & BIOMOLECULAR CHEMISTRY 7 MAY 2014, vol. 12, no. 17, 7 May 2014 (2014-05-07), pages 2675 - 2685, XP002725101, ISSN: 1477-0539
MCCLUSKEY A J ET AL: "Receptor-directed chimeric toxins created by sortase-mediated protein fusion", MOLECULAR CANCER THERAPEUTICS 2013 AMERICAN ASSOCIATION FOR CANCER RESEARCH INC. USA, vol. 12, no. 10, October 2013 (2013-10-01), pages 2273 - 2281, XP002725102, ISSN: 1535-7163
VOLKMANN GERRIT ET AL: "Protein C-Terminal Labeling and Biotinylation Using Synthetic Peptide and Split-Intein", PLOS ONE, vol. 4, no. 12, E8381, 21 December 2009 (2009-12-21), pages 1 - 12, XP002730633, ISSN: 1932-6203
SONG H ET AL: "Protein Trans-Splicing of an Atypical Split Intein Showing Structural Flexibility and Cross-Reactivity", PLOS ONE 20120914 PUBLIC LIBRARY OF SCIENCE USA, vol. 7, no. 9, 14 September 2012 (2012-09-14), XP002730634, ISSN: 1932-6203
Attorney, Agent or Firm:
MICHALSKI HÜTTERMANN & PARTNER PATENTANWÄLTE MBB (Düsseldorf, DE)
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