METHOD FOR PRODUCING ISOTHIAZOLE COMPOUND USING ETHER COMPOUND

Title:

METHOD FOR PRODUCING ISOTHIAZOLE COMPOUND USING ETHER COMPOUND

Document Type and Number:

WIPO Patent Application WO/2015/151491

Kind Code:

A1

Abstract:

[Problem] To provide an industrially preferred method for producing an isothiazole compound, in which the simultaneous use of N,N-dimethylformamide or the like and chlorine is avoided. [Solution] A method for producing an isothiazole compound represented by general formula (3) (wherein R represents a cyano group or the like; and X represents a chlorine atom or the like), said method being characterized by introducing a halogen represented by general formula (2) (wherein X is as defined above) into a nitrile compound represented by general formula (1) (wherein R is as defined above) and sulfur at 70°C or higher in the presence of an ether compound represented by general formula (7) (wherein R1 and R2 may be the same as or different from each other and independently represent an alkyl group or the like) to thereby cause the reaction of the nitrile compound, sulfur and the halogen with one another.

Inventors:

ABE TAKASHI (JP)

Application Number:

PCT/JP2015/001815

Publication Date:

October 08, 2015

Filing Date:

March 30, 2015

Export Citation:

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Assignee:

IHARA CHEMICAL IND CO (JP)

International Classes:

C07D275/02

Domestic Patent References:

WO2010126170A1	2010-11-04
WO2014054294A1	2014-04-10

Foreign References:

JP2010260805A	2010-11-18
US3341547A	1967-09-12
DE2231097A1	1974-01-03
DE2231098A1	1974-01-03

Other References: