Title:
METHOD FOR PRODUCING MACROLIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2024/101298
Kind Code:
A1
Abstract:
Disclosed are a method for producing pladienolide D that includes a step that reacts a compound represented by formula (A1) with a compound represented by formula (B1) in the presence of a metal catalyst to obtain a compound represented by formula (C1) (in the formulas, X means hydrogen, optionally substituted boryl, optionally substituted stannyl, or optionally substituted silyl, R4 is hydrogen, etc., R5 is optionally substituted benzoyl, etc., and R1 and R2 each independently are hydrogen, etc.) and crystals of a solvate of pladienolide D.
Inventors:
YONEDA NAOKI (JP)
SATO NOBUAKI (JP)
NAKAUE TSUBASA (JP)
NAKATANI YUSUKE (JP)
YAMASHITA TARO (JP)
ITO YOKO (JP)
SATO NOBUAKI (JP)
NAKAUE TSUBASA (JP)
NAKATANI YUSUKE (JP)
YAMASHITA TARO (JP)
ITO YOKO (JP)
Application Number:
PCT/JP2023/039845
Publication Date:
May 16, 2024
Filing Date:
November 06, 2023
Export Citation:
Assignee:
EISAI R&D MAN CO LTD (JP)
International Classes:
C07D407/06; C07B61/00; C07D303/16; C07F5/02; C07F5/04
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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