Title:
METHOD FOR PRODUCING MALEATE USING WET CRYSTAL
Document Type and Number:
WIPO Patent Application WO/2012/073508
Kind Code:
A1
Abstract:
[Problem] To efficiently (without carrying out column purification) provide a high-purity maleate having excellent storage stability, solubility, crystallinity and ease of handling according to the present invention. [Solution] This method for producing the maleate represented by formula (1) includes obtaining the compound represented by formula (2) by reacting the compound represented by formula (3) with the compound represented by formula (4) in the presence of a salt, precipitating crystals of the compound represented by formula (2) by mixing the obtained compound represented by formula (2) with acetone and water, and obtaining the maleate represented by formula (1) by adding maleic acid to an acetone solution of the compound represented by formula (2), prepared by dissolving the crystals of the obtained compound represented by formula (2) in acetone.
Inventors:
TSUBUKI TAKESHI (JP)
Application Number:
PCT/JP2011/006704
Publication Date:
June 07, 2012
Filing Date:
November 30, 2011
Export Citation:
Assignee:
KYORIN SEIYAKU KK (JP)
TSUBUKI TAKESHI (JP)
TSUBUKI TAKESHI (JP)
International Classes:
C07D413/14
Domestic Patent References:
| WO2011036895A1 | 2011-03-31 | |||
| WO2008036379A2 | 2008-03-27 |
Foreign References:
| JP2010504334A | 2010-02-12 | |||
| JP2010005786W | 2010-09-27 |
Other References:
SHREDER K.R. ET AL.: "Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3] oxazin-4-one based inhibitors of human neutrophil elastase", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, 2009, pages 4743 - 4746, XP026419069
See also references of EP 2647636A4
See also references of EP 2647636A4
Attorney, Agent or Firm:
MIZUNO, Katsufumi et al. (JP)
Katsufumi Mizuno (JP)
Katsufumi Mizuno (JP)
Download PDF:
Claims:
Previous Patent: SYSTEM, DEVICE, METHOD AND PROGRAM FOR MEASUREMENT OF LEAF AREA INDEX
Next Patent: CLIP
Next Patent: CLIP