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Title:
METHOD FOR PRODUCING NITROGEN-CONTAINING HETEROCYCLE
Document Type and Number:
WIPO Patent Application WO/2012/070509
Kind Code:
A1
Abstract:
A method for producing a compound represented by general formula (I) (wherein R1 represents a protecting group for an amino group, R2, R3, and R4 each independently represent H, OH, an alkenyl group which may be substituted, or an alkoxy group, X represents a halogen-substituted organic group, and R5' is H), an enantiomer thereof, a mixture thereof, or a salt thereof, characterized by comprising reacting a compound represented by general formula (II) (wherein R1, R2, R3, and R4 have the same meanings as described above, and R5 represents OH, an alkylcarbonyloxy group, or an alkoxy group) with XCOOH (X has the same meaning as described above) or a reactive derivative thereof, thereby introducing a carbonyl derivative group represented by XCO (X has the same meaning as described above) at the β-position of the compound.

Inventors:
ONOMURA OSAMU (JP)
KAMOGAWA SATOSHI (JP)
YANAGI TOSHIHARU (JP)
Application Number:
PCT/JP2011/076734
Publication Date:
May 31, 2012
Filing Date:
November 18, 2011
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Assignee:
NAGASAKI UNIVERSITY NAT UNIVERSITY CORP (JP)
NAGASE CHEMTEX CORP (JP)
ONOMURA OSAMU (JP)
KAMOGAWA SATOSHI (JP)
YANAGI TOSHIHARU (JP)
International Classes:
C07D207/20; C07D211/70; C07D221/22
Domestic Patent References:
WO2008117871A12008-10-02
Other References:
BHATTACHARJEE ET AL.: "THE CONFORMATION OF THE BICYCLO(3,3,1)NONANE SYSTEM FROM X-RAY STUDIES", TETRAHEDRON, vol. 35, 1979, pages 1999 - 2007
MELLOR, J. M. ET AL.: "A synthesis of trifluoromethyl-substituted naphthalenes", TETRAHEDRON LETTERS, vol. 41, 2000, pages 7383 - 7386, XP004211930, DOI: doi:10.1016/S0040-4039(00)01254-5
Attorney, Agent or Firm:
IWATANI, Ryo (JP)
Tatsu Iwatani (JP)
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Claims: