METHOD FOR PRODUCING NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE AND PRODUCTION INTERMEDIATE OF SAME

WIPO Patent Application WO/2014/132994

A1

To provide: an industrially useful method for producing a nitrogen-containing heterocyclic derivative which has xanthine oxidase inhibitory activity and is useful as a prophylactic or therapeutic agent for diseases caused by an abnormal serum uric acid level; and a production intermediate for the nitrogen-containing heterocyclic derivative. By using a compound represented by formula (1), a compound represented by formula (2) or a salt thereof can be produced with high yield and high purity. (In formula (1), R1 represents a hydrogen atom or the like; R2 represents a hydroxy group or the like; Y represents a CX4 group or the like; X5 represents a chlorine atom or the like; and each of X1, X2, X3 and X4 independently represents a halogen atom or the like.) (In formula (2), X1-X4, R2 and Y are as defined above.)

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KOBAYASHI MAKOTO (JP)
KIKUCHI NORIHIKO (JP)
AINAI TAKAYUKI (JP)
TAKIGAWA YASUSHI (JP)

PCT/JP2014/054660

September 04, 2014

February 26, 2014

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KISSEI PHARMACEUTICAL (JP)

C07D209/42; C07C253/30; C07C255/42; C07C255/43; C07D213/61; C07D471/04; A61K31/404; A61K31/437; A61P13/02

WO2008126898A1	2008-10-23
WO2008126901A1	2008-10-23

TETRAHEDRON LETTERS, vol. 46, 2005, pages 8877 - 8880
JOURNAL OF ORGANIC CHEMISTRY, vol. 54, 1989, pages 4511 - 4522

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