Title:
METHOD OF PRODUCING NON-BOVINE CHYMOSIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO2002036752
Kind Code:
A3
Abstract:
A method of recombinantly producing a non-bovine pre-prochymosin, prochymosin or chymosin derived from ruminant species including deer species, buffalo species, antelope species, giraffe species, ovine species and caprine species; Camelidae species such as Camelus dromedarius; porcine species; or Equidae species. The recombinant enzymes are used in milk coagulating compositions in cheese manufacturing based on cow's milk and milk from any animal species which are used in cheese manufacturing including camel's milk.
Inventors:
KAPPELER STEFAN (CH)
FARAH ZAKARIA (CH)
BUDTZ PETER (DK)
RAHBEK-NIELSEN HENRIK (DK)
VAN DEN BRINK JOHANNES MAARTEN (DK)
FARAH ZAKARIA (CH)
BUDTZ PETER (DK)
RAHBEK-NIELSEN HENRIK (DK)
VAN DEN BRINK JOHANNES MAARTEN (DK)
Application Number:
PCT/DK2001/000731
Publication Date:
September 26, 2002
Filing Date:
November 06, 2001
Export Citation:
Assignee:
HANSENS LAB (DK)
EIDGENOESS TECH HOCHSCHULE (CH)
KAPPELER STEFAN (CH)
FARAH ZAKARIA (CH)
BUDTZ PETER (DK)
RAHBEK-NIELSEN HENRIK (DK)
VAN DEN BRINK JOHANNES MAARTEN (DK)
EIDGENOESS TECH HOCHSCHULE (CH)
KAPPELER STEFAN (CH)
FARAH ZAKARIA (CH)
BUDTZ PETER (DK)
RAHBEK-NIELSEN HENRIK (DK)
VAN DEN BRINK JOHANNES MAARTEN (DK)
International Classes:
C12N9/64; C12N15/59; (IPC1-7): C12N9/50; C12N15/59; A23C19/032
Domestic Patent References:
| WO2001058924A2 | 2001-08-16 | |||
| WO1996036718A1 | 1996-11-21 | |||
| WO1995029999A2 | 1995-11-09 | |||
| WO1994016086A1 | 1994-07-21 |
Other References:
WARD M ET AL: "IMPROVED PRODUCTION OF CHYMOSIN IN ASPERGILLUS BY EXPRESSION AS A GLUCOAMYLASE-CHYMOSIN FUSION", BIO/TECHNOLOGY, NATURE PUBLISHING CO. NEW YORK, US, vol. 8, no. 5, 1 May 1990 (1990-05-01), pages 435 - 440, XP002013112, ISSN: 0733-222X
WANGOH J ET AL: "Extraction of camel rennet and its comparison with calf rennet extract.", MILCHWISSENSCHAFT, vol. 48, no. 6, 1993, pages 322 - 325, XP002902559
ELSAYED I. ELAGAMY: "Physicochemical, molecular and immunological characterization of camel calf rennet: a comparison with buffalo rennet.", JOURNAL OF DAIRY RESEARCH, vol. 67, 2000, pages 73 - 81, XP002902560
FRANCKY A. ET AL: "A basic residue at position 36p of the propeptide is not essential for the correct folding and subsequent autocatalytic activation of prochymosin.", EUR. J. BIOCHEM., vol. 268, 2001, pages 2362 - 2368, XP002902561
HOUEN G ET AL: "The primary structure and enzymic properties of porcine prochymosin and chymosin", INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY, EXETER, GB, vol. 28, no. 6, 1996, pages 667 - 675, XP002901712, ISSN: 1357-2725
KAPPELER S.: "Compositional and structural analysis of camel milk proteins with emphasis on protective proteins.", DISSERTATION EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE NO 12947, 1998, Swiss Federal Institute of Technology Zurich, pages 1 - 137, XP002902562
WANGOH J ET AL: "Extraction of camel rennet and its comparison with calf rennet extract.", MILCHWISSENSCHAFT, vol. 48, no. 6, 1993, pages 322 - 325, XP002902559
ELSAYED I. ELAGAMY: "Physicochemical, molecular and immunological characterization of camel calf rennet: a comparison with buffalo rennet.", JOURNAL OF DAIRY RESEARCH, vol. 67, 2000, pages 73 - 81, XP002902560
FRANCKY A. ET AL: "A basic residue at position 36p of the propeptide is not essential for the correct folding and subsequent autocatalytic activation of prochymosin.", EUR. J. BIOCHEM., vol. 268, 2001, pages 2362 - 2368, XP002902561
HOUEN G ET AL: "The primary structure and enzymic properties of porcine prochymosin and chymosin", INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY, EXETER, GB, vol. 28, no. 6, 1996, pages 667 - 675, XP002901712, ISSN: 1357-2725
KAPPELER S.: "Compositional and structural analysis of camel milk proteins with emphasis on protective proteins.", DISSERTATION EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE NO 12947, 1998, Swiss Federal Institute of Technology Zurich, pages 1 - 137, XP002902562
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