Title:
METHOD FOR PRODUCING NUCLEIC ACID MOLECULE, BIOMATERIAL, AND METHOD FOR PRODUCING BIOMATERIAL
Document Type and Number:
WIPO Patent Application WO/2021/085554
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method for producing a nucleic acid molecule whereby a nucleic acid molecule, which binds to a target without inhibiting the function of the target, can be acquired. The method according to the preset invention, which is characterized by comprising the following steps (A) and (B), is for producing a nucleic acid molecule which binds to a first biomolecule and does not inhibit the function of the first biomolecule. (A) A step for contacting candidate nucleic acid molecules with the first biomolecule and selecting, as a first selected nucleic acid molecule, a nucleic acid molecule which binds to the first biomolecule. (B) A step for selecting the first selected nucleic acid molecule as the target nucleic acid molecule.
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Inventors:
FUJITA TOMOKO (JP)
WAGA IWAO (JP)
HORII KATSUNORI (JP)
KATO SHINTARO (JP)
STANTON MARTIN (US)
DALBY ANDREW (US)
WAGA IWAO (JP)
HORII KATSUNORI (JP)
KATO SHINTARO (JP)
STANTON MARTIN (US)
DALBY ANDREW (US)
Application Number:
PCT/JP2020/040687
Publication Date:
May 06, 2021
Filing Date:
October 29, 2020
Export Citation:
Assignee:
NEC SOLUTION INNOVATORS LTD (JP)
MOSAIC BIOSCIENCES INC (US)
MOSAIC BIOSCIENCES INC (US)
International Classes:
C12N15/115
Domestic Patent References:
| WO2014128289A1 | 2014-08-28 |
Other References:
MORISHITA, YUKI: "Creation of new RNA aptamer qualified medical material to accelerate the development of functional materials (project/area number 15J10771", ANNUAL RESEARCH REPORT, 16 January 2018 (2018-01-16), Retrieved from the Internet [retrieved on 20201223]
MORISHITA, YUKI ET AL.: "Functional evaluation of RNA aptamer-modified material that specifically complements vascular endothelial cell growth factor", PREPRINTS OF THE 39TH ANNUAL MEETING OF THE JAPANESE SOCIETY FOR BIOMATERIALS, vol. 39, 13 November 2017 (2017-11-13), pages 157
ENAM, S. F. ET AL.: "Enrichment of Endogenous Fractalkine and Anti-Inflammatory Cells via Aptamer-Functionalized Hydrogels", BIOMATERIALS, vol. 142, 10 July 2017 (2017-07-10), pages 52 - 61, XP085147120, DOI: 10.1016/j.biomaterials.2017.07.013
MORISHITA, YUKI ET AL.: "Functional evaluation of RNA aptamer-modified material that specifically complements vascular endothelial cell growth factor", PREPRINTS OF THE 39TH ANNUAL MEETING OF THE JAPANESE SOCIETY FOR BIOMATERIALS, vol. 39, 13 November 2017 (2017-11-13), pages 157
ENAM, S. F. ET AL.: "Enrichment of Endogenous Fractalkine and Anti-Inflammatory Cells via Aptamer-Functionalized Hydrogels", BIOMATERIALS, vol. 142, 10 July 2017 (2017-07-10), pages 52 - 61, XP085147120, DOI: 10.1016/j.biomaterials.2017.07.013
Attorney, Agent or Firm:
TSUJIMARU Koichiro et al. (JP)
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