Title:
METHOD FOR PRODUCING OLIGONUCLEIC ACID COMPOUND
Document Type and Number:
WIPO Patent Application WO/2023/127918
Kind Code:
A1
Abstract:
The present invention relates to a method for producing a morpholino nucleic acid oligomer (each symbol is as defined in the description), the method including a step for treating a compound of formula (II) using a solution that contains an acid and a scavenger in an elongation reaction of a morpholino nucleic acid oligomer represented by the formula and removing R1 from the compound of formula (II) to produce a compound of formula (III).
Inventors:
NOGATA MASAKI (JP)
SHIBA YOSHINOBU (JP)
SHIMOOKA TAKUYA (JP)
YOKOI KENTO (JP)
SHIBA YOSHINOBU (JP)
SHIMOOKA TAKUYA (JP)
YOKOI KENTO (JP)
Application Number:
PCT/JP2022/048385
Publication Date:
July 06, 2023
Filing Date:
December 27, 2022
Export Citation:
Assignee:
NIPPON SHINYAKU CO LTD (JP)
International Classes:
C07F9/6533; C07H21/04
Domestic Patent References:
| WO2012043730A1 | 2012-04-05 | |||
| WO2019216433A1 | 2019-11-14 | |||
| WO2021095874A1 | 2021-05-20 | |||
| WO2021095875A1 | 2021-05-20 | |||
| WO2022230954A1 | 2022-11-03 |
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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