METHOD FOR PRODUCING OPTICALLY ACTIVE 3-(BIPHENYL-4-YL)-2-[(t-BUTOXYCARBONYL)AMINO]PROPAN-1-OL

Title:

METHOD FOR PRODUCING OPTICALLY ACTIVE 3-(BIPHENYL-4-YL)-2-[(t-BUTOXYCARBONYL)AMINO]PROPAN-1-OL

Document Type and Number:

WIPO Patent Application WO/2015/037460

Kind Code:

A1

Abstract:

Optically active 3-(biphenyl-4-yl)-2-[(t-butoxycarbonyl)amino]propan-1-ol can be produced through: a step of reacting an optically active biphenylalanine compound represented by formula [I] with a reducing agent to produce an optically active biphenylalaninol compound represented by formula [II]; and a step of hydrolyzing the optically active biphenylalaninol compound represented by formula [II], which is produced in the proceeding step, under acidic conditions and then reacting the resultant product with t-butyl dicarbonate to produce optically active 3-(biphenyl-4-yl)-2-[(t-butoxycarbonyl)amino]propan-1-ol represented by formula [III].

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Inventors:

TOMOKAWA JUNICHI (JP)
AKIYAMA MASAKI (JP)

Application Number:

PCT/JP2014/072854

Publication Date:

March 19, 2015

Filing Date:

August 26, 2014

Export Citation:

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Assignee:

SUMITOMO CHEMICAL CO (JP)

International Classes:

C07C269/00; C07C233/18; C07C271/16; C07B53/00

Domestic Patent References:

WO2014032627A1

2014-03-06

Foreign References:

JP2007537163A	2007-12-20
CN101362708A	2009-02-11
JP2000344722A	2000-12-12
JP2005082524A	2005-03-31

Attorney, Agent or Firm:

NAKAYAMA, Tohru et al. (JP)
Nakayama 亨 (JP)

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