Title:
METHOD FOR PRODUCING OPTICALLY ACTIVE 5-HYDROXY-3-KETOESTER COMPOUND
Document Type and Number:
WIPO Patent Application WO/2015/030002
Kind Code:
A1
Abstract:
[Problem] The present invention addresses the problem of providing a method for producing an optically active 5-hydroxy-3-ketoester compound which has a high reaction yield and high stereoselectivity, and is useful as an intermediate for a pharmaceutical product. [Solution] A novel production method for obtaining, at a high yield and in a highly selective manner, an optically active 5-hydroxy-3-ketoester compound represented by formula (4) by causing a metal salt and an amine or an ammonium salt and an amine to coexist in the presence of an optically active binaphthol-titanium complex in an asymmetric aldol reaction using 1,3-diene compound.
Inventors:
ISHIDA MARIKO (JP)
TATEYAMA SHOUICHI (JP)
TAKADA YASUTAKA (JP)
NAITOU SHINYA (JP)
KITSUYAMA HIROHIDE (JP)
TATEYAMA SHOUICHI (JP)
TAKADA YASUTAKA (JP)
NAITOU SHINYA (JP)
KITSUYAMA HIROHIDE (JP)
Application Number:
PCT/JP2014/072313
Publication Date:
March 05, 2015
Filing Date:
August 26, 2014
Export Citation:
Assignee:
NISSAN CHEMICAL IND LTD (JP)
International Classes:
C07C67/00; C07C69/738; C07D215/14; C07D239/38; C07B53/00; C07B61/00
Domestic Patent References:
| WO2003042180A1 | 2003-05-22 |
Foreign References:
| JP2009500388A | 2009-01-08 |
Attorney, Agent or Firm:
HANABUSA, Tsuneo et al. (JP)
Sepal Tsuneo (JP)
Sepal Tsuneo (JP)
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