Title:
METHOD FOR PRODUCING OPTICALLY ACTIVE DIAMINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2010/104106
Kind Code:
A1
Abstract:
Disclosed is a method for industrially producing compound (1) and compound (4) to provide an important intermediate for producing an FXa inhibitor. Specifically disclosed is a production method characterized by comprising:
a first step of adding a quaternary ammonium salt and a metal azide salt to water to give an aqueous solution of an azide reagent complex comprising the quaternary ammonium salt- the metal azide salt, and then dehydrating said aqueous solution using an aromatic hydrocarbon-based solvent to thereby give a liquid mixture of the azide reagent complex comprising the quaternary ammonium salt-the metal azide salt with the aromatic hydrocarbon-based solvent having a moisture content less than or equal to 0.2%; and
a second step of adding compound (2) (wherein L represents a leaving group) to the liquid mixture prepared in the aforesaid first step.
Inventors:
KAWANAMI KOUTAROU
Application Number:
PCT/JP2010/053976
Publication Date:
September 16, 2010
Filing Date:
March 10, 2010
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
KAWANAMI KOUTAROU
KAWANAMI KOUTAROU
International Classes:
C07C269/06; C07C269/08; C07C271/24; C07D513/04; C07B53/00; C07B55/00; C07B61/00
Domestic Patent References:
| WO2007032498A1 | 2007-03-22 | |||
| WO2007032498A1 | 2007-03-22 | |||
| WO2004058715A1 | 2004-07-15 | |||
| WO2003016302A1 | 2003-02-27 | |||
| WO2003000680A1 | 2003-01-03 |
Foreign References:
| JPH04227629A | 1992-08-17 | |||
| JP2000344735A | 2000-12-12 | |||
| JPH11180899A | 1999-07-06 |
Other References:
See also references of EP 2407450A4
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
Kimiki Ishibashi (JP)
Kimiki Ishibashi (JP)
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