Title:
METHOD FOR PRODUCING OPTICALLY ACTIVE HYDANTOIN COMPOUND
Document Type and Number:
WIPO Patent Application WO/2015/037243
Kind Code:
A1
Abstract:
The present invention provides a method for producing an optically active hydantoin compound having an LXRβ-activating effect and a production intermediate thereof. In the present invention, an optically active carbinol compound represented by formula (1) is produced by reacting a compound represented by formula (3) and a compound represented by formula (4). In formulas (1), (3), and (4), R1, R2, and R3 show the same or different C1-3 alkyl groups, * shows an asymmetric carbon atom, and R4 shows any one structure selected from A-E.
Inventors:
KOURA MINORU (JP)
SUMIDA HISASHI (JP)
SHIBUYA KIMIYUKI (JP)
SUMIDA HISASHI (JP)
SHIBUYA KIMIYUKI (JP)
Application Number:
PCT/JP2014/004702
Publication Date:
March 19, 2015
Filing Date:
September 11, 2014
Export Citation:
Assignee:
KOWA CO (JP)
International Classes:
C07D403/06; C07B53/00; C07B61/00; C07D233/78; A61K31/496; A61P43/00
Domestic Patent References:
| WO2010125811A1 | 2010-11-04 |
Foreign References:
| JPH05503718A | 1993-06-17 | |||
| JPH07330737A | 1995-12-19 | |||
| JPH1059947A | 1998-03-03 | |||
| JPH11504024A | 1999-04-06 | |||
| DE335993C | 1921-04-20 |
Other References:
DATABASE REGISTRY CHEMICAL ABSTRACTS SERVICE; 25 September 2008 (2008-09-25), accession no. 052555-32-4
DATABASE REGISTRY CHEMICAL ABSTRACTS SERVICE; 17 April 2011 (2011-04-17), accession no. 281562-68-2
DATABASE REGISTRY CHEMICAL ABSTRACTS SERVICE; 17 April 2011 (2011-04-17), accession no. 281562-68-2
Attorney, Agent or Firm:
HIROTA, Masanori (JP)
Masaki Hirota (JP)
Masaki Hirota (JP)
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