Title:
METHOD FOR PRODUCING OPTICALLY ACTIVE N-MONOALKYL-3-HYDROXY-3-ARYLPROPYLAMINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2011/118625
Kind Code:
A1
Abstract:
Disclosed is a method for producing an N-monoalkyl-3-hydroxy-3-arylpropylamine compound which is represented by general formula (2) (therein, Ar represents an optionally substituted aryl group or an optionally substituted heteroaryl group, R represents an optionally substituted alkyl group having 1-5 carbon atoms, and ＊ represents an asymmetric carbon atom), the method being characterised in that an N-benzyl-N-monoalkyl-3-oxo-3-arylpropenylamine compound represented by general formula (1) (therein Ar and R are as above) and hydrogen gas are reacted in the presence of an asymmetric reduction catalyst. Thus, an optically active N-monoalkyl-3-hydroxy-3-arylpropylamine compound can be easily and inexpensively produced under commercially advantageous conditions.
Inventors:
KOGAMI KENJI (JP)
SATAKE SHUZO (JP)
SATAKE SHUZO (JP)
Application Number:
PCT/JP2011/056971
Publication Date:
September 29, 2011
Filing Date:
March 23, 2011
Export Citation:
Assignee:
SUMITOMO SEIKA CHEMICALS (JP)
KOGAMI KENJI (JP)
SATAKE SHUZO (JP)
KOGAMI KENJI (JP)
SATAKE SHUZO (JP)
International Classes:
C07D333/20; C07B53/00; C07B61/00
Domestic Patent References:
| WO2004103990A1 | 2004-12-02 | |||
| WO2003097632A1 | 2003-11-27 |
Foreign References:
| JP2005536556A | 2005-12-02 | |||
| JP2004155770A | 2004-06-03 | |||
| JPH04226948A | 1992-08-17 |
Other References:
SAKURABA S ET AL.: "Practical Asymmetric Synthesis of (R)-Fluoxetine Hydrochloride Catalyzed by (2S,4S)-4-Dicyclohexylphosphino-2-diphenylphosphinomethyl-1-(N-methylcarbamoyl)pyrrolidine-Rhodium Complex", SYNLETT, no. 10, September 1991 (1991-09-01), pages 689 - 690, XP002353757
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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Claims: