Title:
METHOD FOR PRODUCING ORGANIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2018/016376
Kind Code:
A1
Abstract:
The present disclosure provides a reaction of a chlorine-containing compound with use of a flow reactor that has few limits on a solvent to be used therein.
According to the present disclosure, a chlorine-containing compound and a reaction substrate having at least one functional group which is reactive with chlorine and is selected from the group consisting of a hydroxyl group, a thiol group, an amino group, a carboxyl group, a thiocarboxyl group and an acid amide group are supplied to a flow reactor together with an organic solvent and a trialkyl amine having 9-40 carbon atoms, and the reaction substrate and the chlorine-containing compound are reacted with each other, thereby producing an organic compound.
Inventors:
YASUKOUCHI HIROAKI (JP)
MITSUDA MASARU (JP)
NISHIYAMA AKIRA (JP)
FUNABASHI MAKOTO (JP)
MITSUDA MASARU (JP)
NISHIYAMA AKIRA (JP)
FUNABASHI MAKOTO (JP)
Application Number:
PCT/JP2017/025219
Publication Date:
January 25, 2018
Filing Date:
July 11, 2017
Export Citation:
Assignee:
KANEKA CORP (JP)
International Classes:
C07C67/14; C07C69/78; C07C231/02; C07C233/64; C07D235/02; C07D263/44; C07D301/00; C07D303/16
Domestic Patent References:
| WO2014069351A1 | 2014-05-08 |
Foreign References:
| JP2015533802A | 2015-11-26 | |||
| JPH09104642A | 1997-04-22 | |||
| JP2012087105A | 2012-05-10 | |||
| CN102875544A | 2013-01-16 | |||
| JP2007512260A | 2007-05-17 | |||
| US20120053350A1 | 2012-03-01 | |||
| JP2011006367A | 2011-01-13 | |||
| JP2016143646A | 2016-07-21 |
Other References:
SHINICHIRO FUSE ET AL.: "Continuous in situ generation and reaction of phosgene in a microflow system", CHEM. COMMUN., vol. 47, 2011, pages 12661 - 12663, XP055580803, ISSN: 1359-7345, DOI: 10.1039/c1cc15662d
SHINICHIRO FUSE ET AL.: "Efficient Amide Bond Formation through a Rapid and Strong Activation of Carboxylic Acids in a Microflow Reactor", ANGEW. CHEM. INT. ED., vol. 53, 2014, pages 851 - 855, XP055580806, DOI: doi:10.1002/anie.201307987
MURRAY G. ROSENBERG ET AL.: "Inter- and Innermolecular Reactions of Chloro(phenyl)carbene", J. ORG. CHEM., vol. 68, no. 12, 21 May 2003 (2003-05-21), pages 4819 - 4832, XP055602433, ISSN: 0022-3263, DOI: 10.1021/jo026521h
JOEL D. MOORE ET AL.: "High-Load, ROMP-Generated Oligomeric Bis-acid Chlorides: Design of Soluble and Insoluble Nucleophile Scavengers", ORGANIC LETTERS, vol. 5, no. 23, 23 October 2003 (2003-10-23), pages 4241 - 4244, XP055602437, ISSN: 1523-7060, DOI: 10.1021/ol0352759
FUSE ET AL., CHEM. COMMUN., vol. 47, 2011, pages 12661 - 12663
FUSE ET AL., ANGEW. CHEM. INT. ED., vol. 53, 2014, pages 851 - 855
See also references of EP 3489215A4
SHINICHIRO FUSE ET AL.: "Efficient Amide Bond Formation through a Rapid and Strong Activation of Carboxylic Acids in a Microflow Reactor", ANGEW. CHEM. INT. ED., vol. 53, 2014, pages 851 - 855, XP055580806, DOI: doi:10.1002/anie.201307987
MURRAY G. ROSENBERG ET AL.: "Inter- and Innermolecular Reactions of Chloro(phenyl)carbene", J. ORG. CHEM., vol. 68, no. 12, 21 May 2003 (2003-05-21), pages 4819 - 4832, XP055602433, ISSN: 0022-3263, DOI: 10.1021/jo026521h
JOEL D. MOORE ET AL.: "High-Load, ROMP-Generated Oligomeric Bis-acid Chlorides: Design of Soluble and Insoluble Nucleophile Scavengers", ORGANIC LETTERS, vol. 5, no. 23, 23 October 2003 (2003-10-23), pages 4241 - 4244, XP055602437, ISSN: 1523-7060, DOI: 10.1021/ol0352759
FUSE ET AL., CHEM. COMMUN., vol. 47, 2011, pages 12661 - 12663
FUSE ET AL., ANGEW. CHEM. INT. ED., vol. 53, 2014, pages 851 - 855
See also references of EP 3489215A4
Attorney, Agent or Firm:
UEKI, Kyuichi et al. (JP)
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