Title:
METHOD FOR PRODUCING PEPTIDE COMPOUND, REAGENT FOR FORMING PROTECTIVE GROUP, AND SUBSTITUTED BENZYL COMPOUND
Document Type and Number:
WIPO Patent Application WO/2023/106356
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method for producing a peptide compound at a high yield, a reagent for forming a protective group at a high yield, and a novel substituted benzyl compound. The present invention provides a method for producing a peptide compound, said method comprising a step in which a substituted benzyl compound represented by formula (1) is used. In formula (1), Y represents -OH, -NHR, -SH or -X; R represents a hydrogen atom, an alkyl group, an arylalkyl group, a heteroarylalkyl group or a 9-fluorenylmethoxycarbonyl group; X represents Cl, Br or I; m represents 1 or 2; n represents an integer of 1-5; RBs independently represent an aliphatic hydrocarbon group; and RAs independently represent an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group, and at least one of the aliphatic hydrocarbon groups has 12 or more carbon atoms. The benzene ring in formula (1) may further have a substituent in addition to RA.
Inventors:
NAKAGAWA DAISUKE (JP)
TSUYAMA HIROAKI (JP)
YOSHIDA HAYATO (JP)
MOGI TAKUMA (JP)
TSUYAMA HIROAKI (JP)
YOSHIDA HAYATO (JP)
MOGI TAKUMA (JP)
Application Number:
PCT/JP2022/045206
Publication Date:
June 15, 2023
Filing Date:
December 08, 2022
Export Citation:
Assignee:
FUJIFILM CORP (JP)
International Classes:
C07K1/06; C07C43/23; C07C69/712; C07C235/06; C07C271/16
Domestic Patent References:
| WO2007034812A1 | 2007-03-29 | |||
| WO2012165546A1 | 2012-12-06 | |||
| WO2016140232A1 | 2016-09-09 | |||
| WO2004076461A1 | 2004-09-10 |
Foreign References:
| JPH07252187A | 1995-10-03 | |||
| JPS549057B2 | 1974-04-20 | |||
| GB1004281A | 1965-09-15 |
Other References:
MÜLLER KLAUS, MEIER HERBERT, : "Belt-Shaped Cyclophanes via Photodimerization of Phenanthro-Condensed [18]Annulenes", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 61, no. 16, 1 January 1996 (1996-01-01), pages 5474 - 5480, XP093071028, ISSN: 0022-3263, DOI: 10.1021/jo960572v
TAKANORI SUZUKI; YUSUKE ISHIGAKI; TOMOHIRO IWAI; HIDETOSHI KAWAI; KENSHU FUJIWARA; HIROSHI IKEDA; YUSUKE KANO; KAZUHIKO MIZUNO: "Multi‐Input/Multi‐Output Molecular Response System Based on the Dynamic Redox Behavior of 3,3,4,4‐Tetraaryldihydro[5]helicene Derivatives: Reversible Formation/Destruction of Chiral Fluorophore and Modulation of Chiroptical Properties by Solvent Polarity", CHEMISTRY - A EUROPEAN JOURNAL, JOHN WILEY& SONS, INC, DE, vol. 15, no. 37, 20 July 2009 (2009-07-20), DE, pages 9434 - 9441, XP071829495, ISSN: 0947-6539, DOI: 10.1002/chem.200900968
TAKANORI SUZUKI; YUSUKE ISHIGAKI; TOMOHIRO IWAI; HIDETOSHI KAWAI; KENSHU FUJIWARA; HIROSHI IKEDA; YUSUKE KANO; KAZUHIKO MIZUNO: "Multi‐Input/Multi‐Output Molecular Response System Based on the Dynamic Redox Behavior of 3,3,4,4‐Tetraaryldihydro[5]helicene Derivatives: Reversible Formation/Destruction of Chiral Fluorophore and Modulation of Chiroptical Properties by Solvent Polarity", CHEMISTRY - A EUROPEAN JOURNAL, JOHN WILEY& SONS, INC, DE, vol. 15, no. 37, 20 July 2009 (2009-07-20), DE, pages 9434 - 9441, XP071829495, ISSN: 0947-6539, DOI: 10.1002/chem.200900968
Attorney, Agent or Firm:
SIKS & CO. (JP)
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