Title:
METHOD FOR PRODUCING PITAVASTATIN CALCIUM
Document Type and Number:
WIPO Patent Application WO/2017/022846
Kind Code:
A1
Abstract:
According to the present invention, pitavastatin calcium is safely produced at low cost with high yield and high selectivity in an industrial scale. This method for producing pitavastatin calcium is characterized by comprising a step (i) for obtaining a compound represented by general formula (3) through acetalization of a compound represented by general formula (1), a step (ii) for obtaining a compound represented by general formula (4) by reacting the compound represented by general formula (3) with an acid, and a step (iii) for hydrolyzing the compound represented by general formula (4), followed by reaction with a calcium compound.
Inventors:
WATANABE NAOYUKI (JP)
IURA TAKANOBU (JP)
OOMIYA HIDEKI (JP)
NAGAHAMA MASAKI (JP)
IURA TAKANOBU (JP)
OOMIYA HIDEKI (JP)
NAGAHAMA MASAKI (JP)
Application Number:
PCT/JP2016/073056
Publication Date:
February 09, 2017
Filing Date:
August 05, 2016
Export Citation:
Assignee:
API CORP (JP)
International Classes:
C07D215/14; C12P17/12; A61K31/47; A61P3/06; C07B61/00
Domestic Patent References:
| WO2012140490A2 | 2012-10-18 |
Foreign References:
| CN102086184A | 2011-06-08 | |||
| JP2005082591A | 2005-03-31 | |||
| CN101386592A | 2009-03-18 |
Other References:
See also references of EP 3333155A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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