Title:
METHOD FOR PRODUCING PLURIPOTENT STEM CELL HAVING RELEASED DIFFERENTIATION RESISTANCE TO MESENDODERM
Document Type and Number:
WIPO Patent Application WO/2020/090903
Kind Code:
A1
Abstract:
Provided are a method for producing a pluripotent stem cell in which the differentiation resistance to mesendoderm is released, said method comprising subjecting a pluripotent stem cell to a treatment for activating the integrin-β1,β-catenin signaling pathway (excluding a procedure of contacting the pluripotent stem cell with laminin 421 or a fragment thereof and/or laminin 121 or a fragment thereof), etc.
Inventors:
ETO KOJI (JP)
YUZURIHA AKINORI (JP)
YUZURIHA AKINORI (JP)
Application Number:
PCT/JP2019/042608
Publication Date:
May 07, 2020
Filing Date:
October 30, 2019
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
C12N5/071; C12N5/0735; C12N5/10; C12Q1/06
Domestic Patent References:
| WO2017164257A1 | 2017-09-28 | |||
| WO2018128177A1 | 2018-07-12 | |||
| WO2016010082A1 | 2016-01-21 | |||
| WO2018038242A1 | 2018-03-01 | |||
| WO2007069666A1 | 2007-06-21 | |||
| WO1998030679A1 | 1998-07-16 |
Foreign References:
| JP2017023019A | 2017-02-02 | |||
| US5843780A | 1998-12-01 | |||
| JPH11246428A | 1999-09-14 | |||
| JP2018205912A | 2018-12-27 |
Other References:
SATO YOJI, YASUDA SATOSHI, KURODA TAKUYA, JO SHIORI, KUSAKAWA SHINJI, TANO KEIKO, NAKAJIMA HIROYUKI, TAKADA NOZOMI: "Development of cell characterization analysis method using Differentiation propensity as an indicator", SCIENTIFIC RESEARCH GRANTS OF THE MINISTRY OF HEALTH, LABOR, AND WELFARE OF JAPAN FOR HUMAN ES CELLS OR IPS CELLS, COMPREHENSIVE REGULATORY SCIENCE RESEARCH SUCH AS PHARMACEUTICALS AND MEDICAL DEVICE, 16 June 2014 (2014-06-16), JP, pages 117 - 143, XP009528253
HIGUCHI, Y. ET AL.: "Synthesized basement membranes direct the differentiation of mouse embryonic stem cells into pancreatic lineages", JOURNAL OF CELL SCIENCE, vol. 123, no. 16, 2010, pages 2733 - 2742, XP009146306, ISSN: 1477-9137, DOI: 10.1242/jcs.066886
SHIRAKI, N. ET AL.: "Efficient Differentiation of Embryonic Stem Cells into Hepatic Cells In Vitro Using a Feeder-Free Basement Membrane Substratum", PLOS ONE, vol. 6, no. 8, 2011, pages e24228, XP055161523, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0024228
LIU, P. ET AL., NAT. GENET., vol. 22, 1999, pages 361 - 365
HUELSKEN, J. ET AL., J. CELL. BIOL., vol. 148, 2000, pages 567 - 578
WOLL, P.S. ET AL., BLOOD, vol. 111, no. 11, 2008, pages 5298 - 5306
NAKAGAWA ET AL., SCIENTIFIC REPORTS, vol. 4, 2014, pages 3954
THOMSON JA ET AL., PROC NATL. ACAD. SCI. USA., vol. 92, 1995, pages 7844 - 7848
THOMSON ET AL., SCIENCE, vol. 282, 1998, pages 1145 - 1147
H. SUEMORI ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 345, pages 926 - 932
M. UENO ET AL., PROC. NATL. ACAD. SCI. USA, vol. 103, 2006, pages 9554 - 9559
H. SUEMORI ET AL., DEV. DYN., vol. 222, 2001, pages 273 - 279
H. KAWASAKI ET AL., PROC. NATL. ACAD. SCI. USA, vol. 99, 2002, pages 1580 - 1585
KLIMANSKAYA I ET AL., NATURE, vol. 444, 2006, pages 481 - 485
K. TAKAHASHIS. YAMANAKA, CELL, vol. 126, 2006, pages 663 - 676
K. TAKAHASHI ET AL., CELL, vol. 131, 2007, pages 861 - 872
J. YU ET AL., SCIENCE, vol. 318, 2007, pages 1917 - 1920
NAKAGAWA, M. ET AL., NAT. BIOTECHNOL., vol. 26, 2008, pages 101 - 106
KLIMANSKAYA I ET AL., LANCET, vol. 365, 2005, pages 1636 - 1641
"Experimental Medicine Separate Volume ES/iPS Cell Experimental Standard", 2014, YODOSHA CO., LTD.
TAKAYAMAETO, METHODS MOL BIOL., vol. 788, 2012, pages 205 - 17
TAKAAYAMA ET AL., J EXP MED., vol. 207, no. 13, 2010, pages 2817 - 2830
OKITA ET AL., STEM CELLS, vol. 31, 2013, pages 458 - 466
TAKAYAMAETO, METHODS MOL BIOL, vol. 788, 2012, pages 205 - 17
STEM CELL REPORTS, vol. 11, 2018, pages 142 - 156
See also references of EP 3875578A4
HIGUCHI, Y. ET AL.: "Synthesized basement membranes direct the differentiation of mouse embryonic stem cells into pancreatic lineages", JOURNAL OF CELL SCIENCE, vol. 123, no. 16, 2010, pages 2733 - 2742, XP009146306, ISSN: 1477-9137, DOI: 10.1242/jcs.066886
SHIRAKI, N. ET AL.: "Efficient Differentiation of Embryonic Stem Cells into Hepatic Cells In Vitro Using a Feeder-Free Basement Membrane Substratum", PLOS ONE, vol. 6, no. 8, 2011, pages e24228, XP055161523, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0024228
LIU, P. ET AL., NAT. GENET., vol. 22, 1999, pages 361 - 365
HUELSKEN, J. ET AL., J. CELL. BIOL., vol. 148, 2000, pages 567 - 578
WOLL, P.S. ET AL., BLOOD, vol. 111, no. 11, 2008, pages 5298 - 5306
NAKAGAWA ET AL., SCIENTIFIC REPORTS, vol. 4, 2014, pages 3954
THOMSON JA ET AL., PROC NATL. ACAD. SCI. USA., vol. 92, 1995, pages 7844 - 7848
THOMSON ET AL., SCIENCE, vol. 282, 1998, pages 1145 - 1147
H. SUEMORI ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 345, pages 926 - 932
M. UENO ET AL., PROC. NATL. ACAD. SCI. USA, vol. 103, 2006, pages 9554 - 9559
H. SUEMORI ET AL., DEV. DYN., vol. 222, 2001, pages 273 - 279
H. KAWASAKI ET AL., PROC. NATL. ACAD. SCI. USA, vol. 99, 2002, pages 1580 - 1585
KLIMANSKAYA I ET AL., NATURE, vol. 444, 2006, pages 481 - 485
K. TAKAHASHIS. YAMANAKA, CELL, vol. 126, 2006, pages 663 - 676
K. TAKAHASHI ET AL., CELL, vol. 131, 2007, pages 861 - 872
J. YU ET AL., SCIENCE, vol. 318, 2007, pages 1917 - 1920
NAKAGAWA, M. ET AL., NAT. BIOTECHNOL., vol. 26, 2008, pages 101 - 106
KLIMANSKAYA I ET AL., LANCET, vol. 365, 2005, pages 1636 - 1641
"Experimental Medicine Separate Volume ES/iPS Cell Experimental Standard", 2014, YODOSHA CO., LTD.
TAKAYAMAETO, METHODS MOL BIOL., vol. 788, 2012, pages 205 - 17
TAKAAYAMA ET AL., J EXP MED., vol. 207, no. 13, 2010, pages 2817 - 2830
OKITA ET AL., STEM CELLS, vol. 31, 2013, pages 458 - 466
TAKAYAMAETO, METHODS MOL BIOL, vol. 788, 2012, pages 205 - 17
STEM CELL REPORTS, vol. 11, 2018, pages 142 - 156
See also references of EP 3875578A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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