METHOD FOR PRODUCING PYRAZINE DERIVATIVE AND INTERMEDIATE THEREOF

Title:

METHOD FOR PRODUCING PYRAZINE DERIVATIVE AND INTERMEDIATE THEREOF

Document Type and Number:

WIPO Patent Application WO/2010/055884

Kind Code:

A1

Abstract:

A commercially advantageous method for producing a hydroxypyrazine derivative represented by general formula (II) (wherein R1 represents a halo(C1-C6)alkyl group). The method for producing a hydroxypyrazine derivative represented by general formula (II) (wherein R1 is as defined above) is characterized in that a dihydropyrazinone derivative represented by general formula (III) (wherein R1 represents a halo(C1-C6)alkyl group) is dehydrogenated in the presence of an organic base.

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Inventors:

ODA MASATSUGU (JP)
MATSUZAKI YOSHIHIRO (JP)
MORISHITA YUKIO (JP)

Application Number:

PCT/JP2009/069277

Publication Date:

May 20, 2010

Filing Date:

November 12, 2009

Export Citation:

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Assignee:

NIHON NOHYAKU CO LTD (JP)
ODA MASATSUGU (JP)
MATSUZAKI YOSHIHIRO (JP)
MORISHITA YUKIO (JP)

International Classes:

C07D241/08; C07D241/18

Domestic Patent References:

WO2007072999A1	2007-06-28
WO2008089052A2	2008-07-24
WO2006052546A2	2006-05-18

Foreign References:

JPS5762268A	1982-04-15
JPS5762269A	1982-04-15
EP1757595A1	2007-02-28
JP2009242243A	2009-10-22
JP2009242244A	2009-10-22

Other References:

MASUDA, H. ET AL.: "Synthesis of alkoxy-, (alkylthio)-, phenoxy-, and (phenylthio) pyrazines and their olfactive properties", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 34, no. 2, 1986, pages 377 - 8, PAGE 1380
MASUDA, H. ET AL.: "Synthesis of new pyrazines for flavor use", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 29, no. 5, 1981, pages 944 - 7
MCGEE, B.J. ET AL.: "A Chiral 2-D Donor-Acceptor Array of a Bipyrazine N-Oxide and Tetracyanoethylene", ORGANIC LETTERS, vol. 2, no. 9, 2000, pages 1181 - 1184

Attorney, Agent or Firm:

IWATANI, Ryo (JP)
Tatsu Iwatani (JP)

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