Title:
METHOD FOR PRODUCING (R)-2-AMINO-2-ETHYLHEXANOL
Document Type and Number:
WIPO Patent Application WO/2013/058241
Kind Code:
A1
Abstract:
The present invention makes it possible to produce (R)-2-amino-2-ethylhexanol, which is useful as a pharmaceutical intermediate, easily and efficiently without complicated procedures. (R)-2-amino-2-ethylhexanol is produced by asymmetrical alkylation of an N-benzylidene-2-aminoester derivative using an optically active phase-transfer catalyst, followed by debenzylidenation, reduction, and the like. Additionally, a solid (R)-2-amino-2-ethylhexanol salt is obtained and the optical purity is improved by forming a salt with an optically active acid and precipitating a solid.
Inventors:
YOSHIDA FUMI (JP)
HIRAI YOSHINORI (JP)
NISHIYAMA AKIRA (JP)
HIRAI YOSHINORI (JP)
NISHIYAMA AKIRA (JP)
Application Number:
PCT/JP2012/076710
Publication Date:
April 25, 2013
Filing Date:
October 16, 2012
Export Citation:
Assignee:
KANEKA CORP (JP)
International Classes:
C07C213/10; C07B53/00; C07B57/00; C07C59/50; C07C213/00; C07C215/08; C07B61/00
Domestic Patent References:
| WO2008038637A1 | 2008-04-03 | |||
| WO2009125594A1 | 2009-10-15 |
Foreign References:
| JPH10504035A | 1998-04-14 | |||
| JPS5843939A | 1983-03-14 | |||
| JPH08245530A | 1996-09-24 | |||
| JPS60252452A | 1985-12-13 | |||
| JP2886341B2 | 1999-04-26 | |||
| JP2010222358A | 2010-10-07 |
Other References:
DAIGAKUIN YUKI KAGAKU (LAST VOLUME), 1989, pages 661 - 7
YAMADA, SHUNICHI ET AL.: "Asymmetric transamination from amino acids. (III). Asymmetric synthesis of phenylglycine by chemical transamination from optically active amino acids to benzaldehyde", CHEMISTRY LETTERS, 1976, pages 921 - 6
YAMADA, SHUNICHI ET AL.: "Asymmetric transamination from amino acids. (III). Asymmetric synthesis of phenylglycine by chemical transamination from optically active amino acids to benzaldehyde", CHEMISTRY LETTERS, 1976, pages 921 - 6
Attorney, Agent or Firm:
UEKI, Kyuichi et al. (JP)
Hisakazu Ueki (JP)
Hisakazu Ueki (JP)
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Claims: