Title:
METHOD FOR PRODUCING RETINAL TISSUE
Document Type and Number:
WIPO Patent Application WO/2023/003025
Kind Code:
A1
Abstract:
The present disclosure includes a method for producing retinal tissue, the method comprising inducing differentiation of pluripotent stem cells to retinal tissue in a region A on a culture substrate, the culture substrate including on the surface thereof the region A, which has cell adhesiveness, and a region B, which is adjacent to at least a portion of the region A and has a lower cell adhesiveness than the region A. The present disclosure also includes a retinal tissue produced by the method, and a composition containing the retinal tissue.
Inventors:
EIRAKU MOTOTSUGU (JP)
Application Number:
PCT/JP2022/028243
Publication Date:
January 26, 2023
Filing Date:
July 20, 2022
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
A61P9/10; A61K35/30; A61L27/38; A61L27/40; A61P27/02; C07K14/78; C12M3/00; C12N5/07; C12N5/0735; C12N5/10
Domestic Patent References:
| WO2017183732A1 | 2017-10-26 | |||
| WO2007069666A1 | 2007-06-21 | |||
| WO2009006930A1 | 2009-01-15 | |||
| WO2009006997A1 | 2009-01-15 | |||
| WO2009007852A2 | 2009-01-15 | |||
| WO2008118820A2 | 2008-10-02 |
Foreign References:
| JP2021120128A | 2021-08-19 |
Other References:
SODUNKE TEMITOPE R: "Micropatterns of Matrigel for three-dimensional epithelial cultures.", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 28, no. 27, 1 September 2007 (2007-09-01), AMSTERDAM, NL , pages 4006 - 4016, XP002468258, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2007.05.021
HUI ELLIOT E., BHATIA SANGEETA N.: "Microscale Control of Cell Contact and Spacing via Three-Component Surface Patterning", LANGMUIR, AMERICAN CHEMICAL SOCIETY, US, vol. 23, no. 8, 1 April 2007 (2007-04-01), US , pages 4103 - 4107, XP093025747, ISSN: 0743-7463, DOI: 10.1021/la0630559
PAN CHANG-JIANG, DING HONG-YAN, DONG YUN-XIAO: "Extracellular matrix protein patterns guide human chondrocytes adhesion and alignment characterized by vimentin and matrilin-3", COLLOIDS AND SURFACES B: BIOINTERFACES, ELSEVIER AMSTERDAM, NL, vol. 102, 1 February 2013 (2013-02-01), NL , pages 730 - 736, XP093025926, ISSN: 0927-7765, DOI: 10.1016/j.colsurfb.2012.09.005
OVANDO-ROCHE, P. et al. Use of bioreactors for culturing human retinal organoids improves photoreceptor yields. Stem Cell Res. Ther. 2018, 9:156
HIROSHI SHIRAI, MICHIKO MANDAI, KEIZO MATSUSHITA, ATSUSHI KUWAHARA, SHIGENOBU YONEMURA, TOKUSHIGE NAKANO, JUTHAPORN ASSAWACHANANON: "Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 113, no. 1, 5 January 2016 (2016-01-05), pages E81 - E90, XP055396646, ISSN: 0027-8424, DOI: 10.1073/pnas.1512590113
CELL, vol. 126, no. 4, 2006, pages 663 - 676
CELL, vol. 131, no. 5, 2007, pages 861 - 872
SCIENCE, vol. 318, no. 5858, 2007, pages 1917 - 1920
NATURE BIOTECHNOLOGY, vol. 26, no. 1, 2008, pages 1269 - 1275
CELL STEM CELL, vol. 3, no. 5, 2008, pages 475 - 479
CELL STEM CELL, vol. 4, no. 5, 2009, pages 381 - 384
NATURE, vol. 454, 2008, pages 646 - 650
CELL, vol. 136, no. 3, 2009, pages 411 - 419
NATURE CELL BIOLOGY, vol. 11, 2009, pages 197 - 203
CELL, vol. 133, no. 2, 2008, pages 250 - 264
SCIENCE, vol. 341, 2013, pages 651 - 654
STEM CELLS, vol. 31, 2013, pages 458 - 466
PROC. NATL. ACAD. SCI. USA., vol. 105, no. 36, 9 September 2008 (2008-09-09), pages 13409 - 14
HUI ELLIOT E., BHATIA SANGEETA N.: "Microscale Control of Cell Contact and Spacing via Three-Component Surface Patterning", LANGMUIR, AMERICAN CHEMICAL SOCIETY, US, vol. 23, no. 8, 1 April 2007 (2007-04-01), US , pages 4103 - 4107, XP093025747, ISSN: 0743-7463, DOI: 10.1021/la0630559
PAN CHANG-JIANG, DING HONG-YAN, DONG YUN-XIAO: "Extracellular matrix protein patterns guide human chondrocytes adhesion and alignment characterized by vimentin and matrilin-3", COLLOIDS AND SURFACES B: BIOINTERFACES, ELSEVIER AMSTERDAM, NL, vol. 102, 1 February 2013 (2013-02-01), NL , pages 730 - 736, XP093025926, ISSN: 0927-7765, DOI: 10.1016/j.colsurfb.2012.09.005
OVANDO-ROCHE, P. et al. Use of bioreactors for culturing human retinal organoids improves photoreceptor yields. Stem Cell Res. Ther. 2018, 9:156
HIROSHI SHIRAI, MICHIKO MANDAI, KEIZO MATSUSHITA, ATSUSHI KUWAHARA, SHIGENOBU YONEMURA, TOKUSHIGE NAKANO, JUTHAPORN ASSAWACHANANON: "Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 113, no. 1, 5 January 2016 (2016-01-05), pages E81 - E90, XP055396646, ISSN: 0027-8424, DOI: 10.1073/pnas.1512590113
CELL, vol. 126, no. 4, 2006, pages 663 - 676
CELL, vol. 131, no. 5, 2007, pages 861 - 872
SCIENCE, vol. 318, no. 5858, 2007, pages 1917 - 1920
NATURE BIOTECHNOLOGY, vol. 26, no. 1, 2008, pages 1269 - 1275
CELL STEM CELL, vol. 3, no. 5, 2008, pages 475 - 479
CELL STEM CELL, vol. 4, no. 5, 2009, pages 381 - 384
NATURE, vol. 454, 2008, pages 646 - 650
CELL, vol. 136, no. 3, 2009, pages 411 - 419
NATURE CELL BIOLOGY, vol. 11, 2009, pages 197 - 203
CELL, vol. 133, no. 2, 2008, pages 250 - 264
SCIENCE, vol. 341, 2013, pages 651 - 654
STEM CELLS, vol. 31, 2013, pages 458 - 466
PROC. NATL. ACAD. SCI. USA., vol. 105, no. 36, 9 September 2008 (2008-09-09), pages 13409 - 14
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
Download PDF: