Title:
METHOD FOR PRODUCING SELENONEINE
Document Type and Number:
WIPO Patent Application WO/2017/026173
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method for producing selenoneine with which it is possible to produce selenoneine on an industrial scale because selenoneine can be produced at a higher yield than in the prior art. This purpose is achieved by a method for producing selenoneine that includes a step for obtaining selenoneine by subjecting histidine and a selenium compound to the action of a transformant into which a gene that encodes an enzyme of (1) is inserted and which overexpresses the inserted gene. (1) An enzyme that catalyzes a reaction for producing hercynylselenocysteine from histidine and selenocysteine in the presence of S-adenosylmethionine and iron(II)
Inventors:
ICHIKAWA KEIICHI (JP)
SHINOHARA YASUTOMO (JP)
HARA SEIICHI (JP)
KUROSAWA KEIKO (JP)
YAMASHITA YUMIKO (JP)
YAMASHITA MICHIAKI (JP)
SHINOHARA YASUTOMO (JP)
HARA SEIICHI (JP)
KUROSAWA KEIKO (JP)
YAMASHITA YUMIKO (JP)
YAMASHITA MICHIAKI (JP)
Application Number:
PCT/JP2016/068128
Publication Date:
February 16, 2017
Filing Date:
June 17, 2016
Export Citation:
Assignee:
KIKKOMAN CORP (JP)
JAPAN FISHERIES RES AND EDUCATION AGENCY (JP)
JAPAN FISHERIES RES AND EDUCATION AGENCY (JP)
International Classes:
C12P17/10; C12N1/15; C12N15/09; C12N9/02; C12R1/66; C12R1/665; C12R1/685; C12R1/69
Domestic Patent References:
| WO2016121285A1 | 2016-08-04 | |||
| WO2014100752A1 | 2014-06-26 |
Other References:
PLUSKAL, T. ET AL.: "Genetic and metabolomic dissection of the ergothioneine and selenoneine biosynthetic pathway in the fission yeast, S. pombe, and construction of an overproduction system", PLOS ONE, vol. 9, no. 5, 2014, pages 1 - 12, XP055364654, ISSN: 1932-6203
GENGHOF, D. S.: "Biosynthesis of ergothioneine and hercynine by fungi and Actinomycetales", J. BACTERIOL., vol. 103, no. 2, 1970, pages 475 - 478, XP055364661, ISSN: 0021-9193
MELVILLE , D. B. ET AL.: "Ergothioneine in microorganisms.", J. BIOL. CHEM., vol. 223, 1956, pages 9 - 17, XP055364665, ISSN: 0021-9258
VIT, A. ET AL.: "Ergothioneine biosynthetic methyltransferase EgtD reveals the structural basis of aromatic amino acid betaine biosynthesis", CHEMBIOCHEM, vol. 16, 2014, pages 119 - 125, XP055364667, ISSN: 1439-7633
DATABASE protein [O] 4 June 2011 (2011-06-04), "unnamed protein product [Aspergillus oryzae RIB40]", XP055365485, Database accession no. BAE60470
DATABASE protein [O] 16 May 2014 (2014-05-16), "cysteine desulfurase NFS1 [Aspergillus oryzae 100-8]", XP055365486, retrieved from ncbi Database accession no. KDE85407
DATABASE protein [O] 18 June 2012 (2012-06-18), ZHAO,G.: "cysteine desulfurase NFS1 [Aspergillus oryzae 3.042]", XP055365488, retrieved from ncbi Database accession no. EIT79021
BELLO, M. H. ET AL.: "The Neurospora crassa mutant NcDELTAEgt-1 identifies an ergothioneine biosynthetic gene and demonstrates that ergothioneine enhances conidial survival and protects against peroxide toxicity during conidial germination", FUNGAL GENET. BIOL., vol. 49, 2012, pages 160 - 172, XP055266312, ISSN: 1087-1845
See also references of EP 3333266A4
GENGHOF, D. S.: "Biosynthesis of ergothioneine and hercynine by fungi and Actinomycetales", J. BACTERIOL., vol. 103, no. 2, 1970, pages 475 - 478, XP055364661, ISSN: 0021-9193
MELVILLE , D. B. ET AL.: "Ergothioneine in microorganisms.", J. BIOL. CHEM., vol. 223, 1956, pages 9 - 17, XP055364665, ISSN: 0021-9258
VIT, A. ET AL.: "Ergothioneine biosynthetic methyltransferase EgtD reveals the structural basis of aromatic amino acid betaine biosynthesis", CHEMBIOCHEM, vol. 16, 2014, pages 119 - 125, XP055364667, ISSN: 1439-7633
DATABASE protein [O] 4 June 2011 (2011-06-04), "unnamed protein product [Aspergillus oryzae RIB40]", XP055365485, Database accession no. BAE60470
DATABASE protein [O] 16 May 2014 (2014-05-16), "cysteine desulfurase NFS1 [Aspergillus oryzae 100-8]", XP055365486, retrieved from ncbi Database accession no. KDE85407
DATABASE protein [O] 18 June 2012 (2012-06-18), ZHAO,G.: "cysteine desulfurase NFS1 [Aspergillus oryzae 3.042]", XP055365488, retrieved from ncbi Database accession no. EIT79021
BELLO, M. H. ET AL.: "The Neurospora crassa mutant NcDELTAEgt-1 identifies an ergothioneine biosynthetic gene and demonstrates that ergothioneine enhances conidial survival and protects against peroxide toxicity during conidial germination", FUNGAL GENET. BIOL., vol. 49, 2012, pages 160 - 172, XP055266312, ISSN: 1087-1845
See also references of EP 3333266A4
Attorney, Agent or Firm:
MORIMOTO, Toshiaki (JP)
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