Title:
METHOD FOR PRODUCING SIDE CHAIN PRECURSOR OF PACLITAXEL AND DOCETAXEL
Document Type and Number:
WIPO Patent Application WO/2017/006573
Kind Code:
A1
Abstract:
A side chain precursor of paclitaxel and docetaxel is provided at high purity, high yield, and low cost through a method for producing a compound shown by formula (3) using a compound shown by formula (1) as a starting compound. Using the side chain precursor thus obtained makes it possible to provide paclitaxel and docetaxel that are useful as anticancer agents. (In formula (1), R1 is an alkoxy group, arylalkyloxy group, alkylsilyloxy group, or alkoxycarbonyloxy group, R2 is an aryl group, X is one selected from the group consisting of substituents shown by formula (2), and Y is a hydrogen atom or methyl group.) (In formula (3), R2 is defined in the same way as in formula (1), and R3 is an alkoxy group.)
Inventors:
MANDAI TADAKATSU (JP)
Application Number:
PCT/JP2016/051372
Publication Date:
January 12, 2017
Filing Date:
January 19, 2016
Export Citation:
Assignee:
MANDAI TADAKATSU (JP)
ENSUIKO SUGAR REFINING (JP)
ENSUIKO SUGAR REFINING (JP)
International Classes:
C07D263/06; C07C229/34; C07C251/36; C07C271/22; C07D305/14
Domestic Patent References:
| WO2008054233A2 | 2008-05-08 |
Foreign References:
| CN101033216A | 2007-09-12 | |||
| JP2001089464A | 2001-04-03 | |||
| JP2004531498A | 2004-10-14 | |||
| JP2000500437A | 2000-01-18 |
Other References:
MICHALAK, O. ET AL.: "A novel synthesis of antineoplastic drug docetaxel", PRZEMYSL CHEMICZNY, vol. 86, no. 8, 2007, pages 783 - 788, ISSN: 0033-2496
MANDAI, T. ET AL.: "Synthesis and biological evaluation of water soluble taxoids bearing sugar moieties", HETEROCYCLES, vol. 54, no. 2, 2001, pages 561 - 566, XP001536935, ISSN: 0385-5414, DOI: doi:10.3987/COM-00-S(I)34
MANDAI, T. ET AL.: "Synthesis and biological evaluation of water soluble taxoids bearing sugar moieties", HETEROCYCLES, vol. 54, no. 2, 2001, pages 561 - 566, XP001536935, ISSN: 0385-5414, DOI: doi:10.3987/COM-00-S(I)34
Attorney, Agent or Firm:
SETOUCHI INTERNATIONAL PATENT FIRM (JP)
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