Title:
METHOD FOR PRODUCING SILANE-CONTAINING CONDENSED RING DIPEPTIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2023/243720
Kind Code:
A1
Abstract:
Provided is a method for producing a silane-containing condensed ring dipeptide compound represented by formula (A). The method comprises: (i) a step for reacting a first amino acid represented by formula (R1) with a first silane compound represented by formula (S1); (ii) a step for reacting a second amino acid represented by formula (R2) with a second silane compound represented by formula (S2); and (iii) a step for mixing and further reacting the reaction product in step (i) with the reaction product in step (ii) to obtain the condensed ring dipeptide compound represented by formula (A). (The definitions of the respective substituents in the formulae are as described in the claims.)
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Inventors:
YAMAMOTO HISASHI (JP)
HATTORI TOMOHIRO (JP)
HATTORI TOMOHIRO (JP)
Application Number:
PCT/JP2023/022441
Publication Date:
December 21, 2023
Filing Date:
June 16, 2023
Export Citation:
Assignee:
CHUBU UNIV EDUCATIONAL FOUNDATION (JP)
International Classes:
C07F7/18; C07K1/02; C07K5/06
Domestic Patent References:
| WO2022190486A1 | 2022-09-15 |
Other References:
KOWALKE JANINE; BRENDLER ERICA; WAGLER JÖRG: "Valinate and SiMe2 – An interesting couple in pentacoordinate Si-complexes: Templated generation of the dipeptide val-val and formation of an organosilicon-ammonia-adduct", JOURNAL OF ORGANOMETALLIC CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 956, 16 October 2021 (2021-10-16), AMSTERDAM, NL , XP086861851, ISSN: 0022-328X, DOI: 10.1016/j.jorganchem.2021.122126
HATTORI TOMOHIRO, YAMAMOTO HISASHI: "Synthesis of Silacyclic Dipeptides: Peptide Elongation at Both N- and C-Termini of Dipeptide", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 144, no. 4, 2 February 2022 (2022-02-02), pages 1758 - 1765, XP093117053, ISSN: 0002-7863, DOI: 10.1021/jacs.1c11260
HATTORI TOMOHIRO, YAMAMOTO HISASHI: "Synthesis of Silacyclic Dipeptides: Peptide Elongation at Both N- and C-Termini of Dipeptide", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 144, no. 4, 2 February 2022 (2022-02-02), pages 1758 - 1765, XP093117053, ISSN: 0002-7863, DOI: 10.1021/jacs.1c11260
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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