Title:
METHOD FOR PRODUCING SOLID TRIAZOLINEDIONE COMPOUND, SOLID TRIAZOLINEDIONE COMPOUND, AND METHOD FOR PRODUCING TRIAZOLINEDIONE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2019/240140
Kind Code:
A1
Abstract:
Provided are a method for separating a DAPTAD-containing triazolinedione compound in solid form from a reaction solution, a separated solid triazolinedione compound, and a novel method for producing a triazolinedione compound. A triazolinedione solution in which a DAPTAD-containing triazolinedione compound is dissolved is brought into contact with a C5-15 hydrocarbon-based poor solvent to obtain a solid triazolinedione compound. Also, a triazolinedione compound is oxidized using an oxidizing agent that does not produce acid as a byproduct to obtain a triazolinedione compound.
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Inventors:
SEKI MASAHIKO (JP)
FUKUZAWA SEKETSU (JP)
TAKIWAKI MASAKI (JP)
FUKUZAWA SEKETSU (JP)
TAKIWAKI MASAKI (JP)
Application Number:
PCT/JP2019/023163
Publication Date:
December 19, 2019
Filing Date:
June 11, 2019
Export Citation:
Assignee:
TOKUYAMA CORP (JP)
JEOL LTD (JP)
JEOL LTD (JP)
International Classes:
C07D249/12
Foreign References:
| JPS62124134A | 1987-06-05 | |||
| JP2015166740A | 2015-09-24 |
Other References:
ROY NABARUN ET AL.: "Dynamic Covalent Chemistry: A Facile Room-Temperature, Reversible, Diels-Alder Reaction between Anthracene Derivatives and N-Phenyltriazolinedione", CHEMISTRY - AN ASIAN JOURNAL, vol. 6, no. 9, 5 September 2011 (2011-09-05), pages 2419 - 2425, XP055663155, ISSN: 1861-4728, DOI: 10.1002/asia.201100244
WERNER STEFAN ET AL.: "Fluorous Dienophiles Are Powerful Diene Scavengers in Diels-Alder Reactions", ORGANIC LETTERS, vol. 5, no. 18, 2003, pages 3293 - 3296, XP055663163, ISSN: 1523-7060, DOI: 10.1021/ol035214a
BURRAGE MARTIN E. ET AL.: "Substituent and solvent effects on the Diels-Alder reactions of triazolinediones", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 2, vol. 12, 1 January 1975 (1975-01-01), pages 1325 - 1334, XP055663220, DOI: 10.1039/P29750001325
OGAWA SHOUJIRO ET AL.: "Comparative evaluation of new Cookson-type reagents for LC/ESI-MS/MS assay of 25-hydroxyvitamin D3 in neonatal blood samples", BIOMEDICAL CHROMATOGRAPHY, vol. 30, no. 6, 1 June 2016 (2016-06-01), pages 938 - 945, XP055434371, ISSN: 0269-3879, DOI: 10.1002/bmc.3633
OGAWA SHOUJIRO ET AL.: "A novel Cookson-type reagent for enhancing sensitivity and specificity in assessment of infant vitamin D status using liquid chromatography/tandem mass spectrometry", RAPID COMMUN. MASS SPECTROM., vol. 27, no. 21, 15 November 2013 (2013-11-15), pages 2453 - 2460, XP055664200, ISSN: 0951-4198, DOI: 10.1002/rcm.6708
S. OGAWA ET AL., RAPID COMMUN. MASS SPECTROM, vol. 27, 2013, pages 2453 - 2460
S. OGAWA ET AL., BIOMED. CHROMATGR., vol. 30, 2016, pages 938 - 945
S. OGAWA ET AL., J. PHARM. BIOMED. ANAL., vol. 136, 2017, pages 126 - 133
K.D. BRUYCKER ET AL., CHEM. REV., vol. 116, 2016, pages 3919 - 3974
See also references of EP 3712137A4
WERNER STEFAN ET AL.: "Fluorous Dienophiles Are Powerful Diene Scavengers in Diels-Alder Reactions", ORGANIC LETTERS, vol. 5, no. 18, 2003, pages 3293 - 3296, XP055663163, ISSN: 1523-7060, DOI: 10.1021/ol035214a
BURRAGE MARTIN E. ET AL.: "Substituent and solvent effects on the Diels-Alder reactions of triazolinediones", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 2, vol. 12, 1 January 1975 (1975-01-01), pages 1325 - 1334, XP055663220, DOI: 10.1039/P29750001325
OGAWA SHOUJIRO ET AL.: "Comparative evaluation of new Cookson-type reagents for LC/ESI-MS/MS assay of 25-hydroxyvitamin D3 in neonatal blood samples", BIOMEDICAL CHROMATOGRAPHY, vol. 30, no. 6, 1 June 2016 (2016-06-01), pages 938 - 945, XP055434371, ISSN: 0269-3879, DOI: 10.1002/bmc.3633
OGAWA SHOUJIRO ET AL.: "A novel Cookson-type reagent for enhancing sensitivity and specificity in assessment of infant vitamin D status using liquid chromatography/tandem mass spectrometry", RAPID COMMUN. MASS SPECTROM., vol. 27, no. 21, 15 November 2013 (2013-11-15), pages 2453 - 2460, XP055664200, ISSN: 0951-4198, DOI: 10.1002/rcm.6708
S. OGAWA ET AL., RAPID COMMUN. MASS SPECTROM, vol. 27, 2013, pages 2453 - 2460
S. OGAWA ET AL., BIOMED. CHROMATGR., vol. 30, 2016, pages 938 - 945
S. OGAWA ET AL., J. PHARM. BIOMED. ANAL., vol. 136, 2017, pages 126 - 133
K.D. BRUYCKER ET AL., CHEM. REV., vol. 116, 2016, pages 3919 - 3974
See also references of EP 3712137A4
Attorney, Agent or Firm:
KATO Ryuta et al. (JP)
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