Title:
METHOD OF PRODUCING STRUCTURES USING CENTRIFUGAL FORCES
Document Type and Number:
WIPO Patent Application WO2004071736
Kind Code:
A3
Abstract:
A variety of hollow structures with unique morphologies were manufactured with a rotational spinning technique. Phase separation of soluble solutions or emulsions was induced within a filled mold as it was being rotated about one of its axis. The density difference between phases results in sediment at the inner lumen of the mold under centrifugal forces. After or during sedimentation, gelation of the phase-separated particles fixes the hollow structure morphology and the solvent remains in the center of the mold. The solvent is removed from the mold resulting in a coating or tube. By controlling the rotational speed and the formulation chemistry, the tube dimensions and wall morphology can be manipulated. This technique offers a new approach to the manufacture of polymeric tubes. It requires small quantities of starting material, permits multi-layering of tubes, is applicable to diverse polymers and can result in highly diffusive hollow structures while maintaining good mechanical strength.
Inventors:
DALTON PAUL D (DE)
SHOICHET MOLLY S (CA)
LEVESQUE STEPHANE G (CA)
FREIER THOMAS (CA)
CHUNG WILLIAM (CA)
SHOICHET MOLLY S (CA)
LEVESQUE STEPHANE G (CA)
FREIER THOMAS (CA)
CHUNG WILLIAM (CA)
Application Number:
PCT/CA2004/000191
Publication Date:
October 28, 2004
Filing Date:
February 13, 2004
Export Citation:
Assignee:
MATREGEN CORP (CA)
DALTON PAUL D (DE)
SHOICHET MOLLY S (CA)
LEVESQUE STEPHANE G (CA)
FREIER THOMAS (CA)
CHUNG WILLIAM (CA)
DALTON PAUL D (DE)
SHOICHET MOLLY S (CA)
LEVESQUE STEPHANE G (CA)
FREIER THOMAS (CA)
CHUNG WILLIAM (CA)
International Classes:
A61K9/00; B29C39/00; B29C39/08; B29C41/00; B29C41/04; B29C41/50; B29C67/02; B32B1/08; A61B17/11; A61K9/16; A61K9/70; B29C37/00; (IPC1-7): B29C41/04; B29C41/50; A61L27/00; A61L31/00; A61K9/00; A61B17/11
Domestic Patent References:
| WO2001085417A1 | 2001-11-15 |
Foreign References:
| US5266325A | 1993-11-30 | |||
| US5292515A | 1994-03-08 | |||
| US5656605A | 1997-08-12 |
Other References:
DALTON P D ET AL: "Creating porous tubes by centrifugal forces for soft tissue application", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 22, no. 19, 1 October 2001 (2001-10-01), pages 2661 - 2669, XP004296086, ISSN: 0142-9612
DALTON P D ET AL: "Manufacture of poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) hydrogel tubes for use as nerve guidance channels", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 23, no. 18, September 2002 (2002-09-01), pages 3843 - 3851, XP004372495, ISSN: 0142-9612
VACHOUD L ET AL: "Physicochemical behaviour of chitin gels", CARBOHYDRATE RESEARCH, ELSEVIER SCIENTIFIC PUBLISHING COMPANY. AMSTERDAM, NL, vol. 326, no. 4, June 2000 (2000-06-01), pages 295 - 304, XP004205958, ISSN: 0008-6215
MADIHALLY S. V., MATTHEW H. W. T: "Porous chitosan scaffolds for tissue engineering", BIOMATERIALS, vol. 20, no. 12, June 1999 (1999-06-01), XP002286582, Retrieved from the Internet [retrieved on 20040630]
GONG HAIPENG, ZHANG XIUFANG: "Studies on nerve cell affinity of chitosan-derived materials", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, vol. 52, no. 2, 15 August 2000 (2000-08-15), pages 285 - 295, XP002286583, Retrieved from the Internet
DALTON P D ET AL: "Manufacture of poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) hydrogel tubes for use as nerve guidance channels", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 23, no. 18, September 2002 (2002-09-01), pages 3843 - 3851, XP004372495, ISSN: 0142-9612
VACHOUD L ET AL: "Physicochemical behaviour of chitin gels", CARBOHYDRATE RESEARCH, ELSEVIER SCIENTIFIC PUBLISHING COMPANY. AMSTERDAM, NL, vol. 326, no. 4, June 2000 (2000-06-01), pages 295 - 304, XP004205958, ISSN: 0008-6215
MADIHALLY S. V., MATTHEW H. W. T: "Porous chitosan scaffolds for tissue engineering", BIOMATERIALS, vol. 20, no. 12, June 1999 (1999-06-01), XP002286582, Retrieved from the Internet
GONG HAIPENG, ZHANG XIUFANG: "Studies on nerve cell affinity of chitosan-derived materials", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, vol. 52, no. 2, 15 August 2000 (2000-08-15), pages 285 - 295, XP002286583, Retrieved from the Internet
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