Title:
METHOD FOR PRODUCING TETRAHYDROFURAN-2-CARBOXYLIC ACID
Document Type and Number:
WIPO Patent Application WO/2021/261393
Kind Code:
A1
Abstract:
Provided is a method suited to industrial production of tetrahydrofuran-2-carboxylic acid, which is important as a pharmaceutical raw material, etc. The method for producing tetrahydrofuran-2-carboxylic acid produces tetrahydrofuran-2-carboxylic acid by adding a 0-0.5-fold molar quantity of a base per 1 mol of furan-2-carboxylic acid in the presence of a palladium-carbon catalyst to subject furan-2-carboxylic acid and hydrogen to a catalytic hydrogenation reaction at 100℃ in an aqueous solvent.
Inventors:
MORII SEIJI (JP)
NISHIKAWA IZUMI (JP)
HIRAGA HISAFUMI (JP)
NISHIKAWA IZUMI (JP)
HIRAGA HISAFUMI (JP)
Application Number:
PCT/JP2021/023192
Publication Date:
December 30, 2021
Filing Date:
June 18, 2021
Export Citation:
Assignee:
TORAY FINECHEMICALS CO LTD (JP)
International Classes:
C07D307/24; C07B61/00
Foreign References:
| US3225066A | 1965-12-21 | |||
| CN109331814A | 2019-02-15 | |||
| US3342838A | 1967-09-19 | |||
| JPH03188072A | 1991-08-16 |
Other References:
KARPOV, A. A. ET AL.: "Catalytic hydrogenation of 2-furan- and 2- and 3- pyridinecarboxylic acids, Izvestiya Vysshikh Uchebnykh Zavedenii", KHIMIYA I KHIMICHESKAYA TEKHNOLOGIYA, vol. 50, no. 4, 2007, pages 44 - 46, ISSN: 0579-2991
MARIS MIHAELA, TAMAS MALLAT, ELISABETH ORGLMEISTER, ALFONS BAIKER: "On the role of modifier structure in the palladium-catalyzed enantioselective hydrogenation of furan-2- carlloxylic acid", JOURNAL OF MOLECULAR CATALYSIS A: CHEMICAL, vol. 219, no. 2, 1 September 2004 (2004-09-01), pages 371 - 376, XP055895795, DOI: 10.1016/j.molcata. 2004.05.03 1
ZHU, R. ET AL.: "Cascade conversion of furancarboxylic acid to butanediol diacetate over Pd/C and La(OTf)3 catalytic system", APPLIED CATALYSIS, A: GENERAL, 25 October 2020 (2020-10-25), XP086352186, DOI: 10.1016/j.apcata.2020.117888
MARIS MIHAELA, TAMAS MALLAT, ELISABETH ORGLMEISTER, ALFONS BAIKER: "On the role of modifier structure in the palladium-catalyzed enantioselective hydrogenation of furan-2- carlloxylic acid", JOURNAL OF MOLECULAR CATALYSIS A: CHEMICAL, vol. 219, no. 2, 1 September 2004 (2004-09-01), pages 371 - 376, XP055895795, DOI: 10.1016/j.molcata. 2004.05.03 1
ZHU, R. ET AL.: "Cascade conversion of furancarboxylic acid to butanediol diacetate over Pd/C and La(OTf)3 catalytic system", APPLIED CATALYSIS, A: GENERAL, 25 October 2020 (2020-10-25), XP086352186, DOI: 10.1016/j.apcata.2020.117888
Attorney, Agent or Firm:
SEIRYU PATENT PROFESSIONAL CORPORATION et al. (JP)
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