Title:
METHOD FOR PRODUCING TETRAHYDROPYRAN COMPOUND AND INTERMEDIATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/119890
Kind Code:
A1
Abstract:
Disclosed is a method for producing a tetrahydropyran compound represented by general formula (5) shown in the scheme. Accordingly, a tetrahydropyran derivative is obtained in high yield and with high selectivity without using a highly toxic reagent, and an industrially useful method for producing a tetrahydropyran derivative and an intermediate thereof can be provided. In formulae (1) to (5), R1 and R2 each independently represent a hydrogen atom, a linear, branched, or cyclic alkyl group, or an aromatic group which may have a substituent, and R1 and R2 may be combined to form an alkylene group, thereby forming a ring; and R3 and R4 each independently represent a hydrogen atom or a linear, branched, or cyclic alkyl group, and R3 and R4 may be combined to form an alkylene group, thereby forming a ring.
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Inventors:
KAWANAMI HIROTAKA (JP)
UEDA KANA (JP)
MURASE SHOTA (JP)
UEDA KANA (JP)
MURASE SHOTA (JP)
Application Number:
PCT/JP2010/056670
Publication Date:
October 21, 2010
Filing Date:
April 14, 2010
Export Citation:
Assignee:
NISSAN CHEMICAL IND LTD (JP)
KAWANAMI HIROTAKA (JP)
UEDA KANA (JP)
MURASE SHOTA (JP)
KAWANAMI HIROTAKA (JP)
UEDA KANA (JP)
MURASE SHOTA (JP)
International Classes:
C07D493/04; C07D317/20
Domestic Patent References:
| WO2005118565A1 | 2005-12-15 | |||
| WO2005118565A1 | 2005-12-15 |
Other References:
JIANG, S. ET AL.: "Diastereoselective reduction of hemiacetals derived from 2,3-0- isopropylidene derivatives of carbohydrate lactones", CHEMISTRY LETTERS, no. 1, 1996, pages 67 - 68, XP008153619
H CHOI ET AL.: "Synthetic studies on the marine natural product halichondrins", PURE AND APPLIED CHEMISTRY, vol. 75, no. 1, 2003, pages 1 - 17
KALIAPPAN, K.P. ET AL.: "Design and synthesis of novel oxa-bridged isoxazolidines and 1,3-aminoalcohols", TETRAHEDRON LETTERS, vol. 46, no. 17, 2005, pages 3037 - 3040, XP027863536
PURE APPL. CHEM., vol. 75, no. 1, 2003, pages 1 - 17
See also references of EP 2420504A4
H CHOI ET AL.: "Synthetic studies on the marine natural product halichondrins", PURE AND APPLIED CHEMISTRY, vol. 75, no. 1, 2003, pages 1 - 17
KALIAPPAN, K.P. ET AL.: "Design and synthesis of novel oxa-bridged isoxazolidines and 1,3-aminoalcohols", TETRAHEDRON LETTERS, vol. 46, no. 17, 2005, pages 3037 - 3040, XP027863536
PURE APPL. CHEM., vol. 75, no. 1, 2003, pages 1 - 17
See also references of EP 2420504A4
Attorney, Agent or Firm:
KOJIMA TAKASHI (JP)
Takashi Kojima (JP)
Takashi Kojima (JP)
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