Title:
METHOD FOR PRODUCING URACIL COMPOUND
Document Type and Number:
WIPO Patent Application WO/2023/286719
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing: an industrially advantageous method for producing a uracil compound, which is a production intermediate of a 2,6-dioxo-3,6-dihydropyrimidine compound; and a ureidomethylene compound to serve as a raw material of a uracil compound. The present invention is characterized by producing a uracil compound, which is a production intermediate of a 2,6-dioxo-3,6-dihydropyrimidine compound, by chemically reacting a compound represented by formula (II) or a salt thereof in the presence of an organic base or an inorganic base. In formula (II), X1 represents a hydrogen atom or a substituted or unsubstituted C1-6 alkyl group, X2 represents a hydrogen atom, a substituted or unsubstituted linear C1-6 alkyl group, etc., R1 represents a hydrogen atom, a substituted or unsubstituted C1-6 alkyl group, etc., R2 represents a hydrogen atom or a substituted or unsubstituted C1-6 alkyl group, and R3 represents a substituted or unsubstituted C1-6 alkyl group, etc.
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Inventors:
ISHIHARA TAKUMA (JP)
KOUBORI SHINYA (JP)
TERANISHI TAKAAKI (JP)
KOUBORI SHINYA (JP)
TERANISHI TAKAAKI (JP)
Application Number:
PCT/JP2022/027185
Publication Date:
January 19, 2023
Filing Date:
July 11, 2022
Export Citation:
Assignee:
NIPPON SODA CO (JP)
International Classes:
C07D239/54; C07C275/16; C07C275/20; C07D405/12; C07D417/12
Domestic Patent References:
| WO2021085389A1 | 2021-05-06 | |||
| WO2006135763A2 | 2006-12-21 | |||
| WO2019213340A1 | 2019-11-07 | |||
| WO2018122559A1 | 2018-07-05 | |||
| WO2021085389A1 | 2021-05-06 |
Foreign References:
| US20210077492A1 | 2021-03-18 | |||
| JP2021512055A | 2021-05-13 | |||
| JP2021504367A | 2021-02-15 | |||
| JP2020535168A | 2020-12-03 | |||
| JP2017500362A | 2017-01-05 | |||
| JP2016522263A | 2016-07-28 | |||
| JP2014533287A | 2014-12-11 | |||
| JP2021115884A | 2021-08-10 | |||
| JP2021131516A | 2021-09-09 |
Other References:
BOITEAU JEAN-GUY; BOUIX-PETER CLAIRE; CHAMBON SANDRINE; CLARY LAURENCE; DAVER SEBASTIEN; DUMAIS LAURENCE; FOURNIER JEAN-FRANÇOIS; : "An efficient multi-component synthesis of N-1-alkylated 5-nitrouracils from alpha-amino acids", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 57, no. 22, 22 April 2016 (2016-04-22), Amsterdam , NL , pages 2367 - 2371, XP029531740, ISSN: 0040-4039, DOI: 10.1016/j.tetlet.2016.04.039
Attorney, Agent or Firm:
HIROTA, Masanori (JP)
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