Title:
METHOD FOR THE PRODUCTION OF 1-[N<2>-[3,5-DIBROMO-N-[[4-(3,4-DIHYDRO-2(1H)-OXOQUINAZOLINE-3-YL)-1-PIPERIDINYL]CARBONYL]-D-TYROSYL]-L-LYSYL]-4-(4-PYRIDINYL)-PIPERAZINE
Document Type and Number:
WIPO Patent Application WO2005077931
Kind Code:
A3
Abstract:
The invention relates to a method for producing the CGRP antagonist 1-[N<2>-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazoline-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-Iysyl]-4-(4-pyridinyl)-piperazine of formula (I). The disclosed method allows said compound to be produced in great quantities, at great yields, and at a high degree of purity.
Inventors:
LINZ GUENTER (DE)
BROEDER WOLFGANG (DE)
ZERBAN GEORG (DE)
WINTER ERIC (DE)
SCHMITT BERND (DE)
RENNER SVENJA (DE)
WEYELL BJOERN (DE)
SCHMITT HEINZ-PETER (DE)
BROEDER WOLFGANG (DE)
ZERBAN GEORG (DE)
WINTER ERIC (DE)
SCHMITT BERND (DE)
RENNER SVENJA (DE)
WEYELL BJOERN (DE)
SCHMITT HEINZ-PETER (DE)
Application Number:
PCT/EP2005/001188
Publication Date:
December 22, 2005
Filing Date:
February 05, 2005
Export Citation:
Assignee:
BOEHRINGER INGELHEIM INT (DE)
BOEHRINGER INGELHEIM PHARMA (DE)
LINZ GUENTER (DE)
BROEDER WOLFGANG (DE)
ZERBAN GEORG (DE)
WINTER ERIC (DE)
SCHMITT BERND (DE)
RENNER SVENJA (DE)
WEYELL BJOERN (DE)
SCHMITT HEINZ-PETER (DE)
BOEHRINGER INGELHEIM PHARMA (DE)
LINZ GUENTER (DE)
BROEDER WOLFGANG (DE)
ZERBAN GEORG (DE)
WINTER ERIC (DE)
SCHMITT BERND (DE)
RENNER SVENJA (DE)
WEYELL BJOERN (DE)
SCHMITT HEINZ-PETER (DE)
International Classes:
C07D401/04; C07D401/14; C07K5/065; (IPC1-7): C07D401/14; C07K5/06
Domestic Patent References:
| WO2001049676A1 | 2001-07-12 | |||
| WO2000055154A1 | 2000-09-21 | |||
| WO1998011128A1 | 1998-03-19 |
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