Title:
METHOD FOR THE PRODUCTION OF 3-AMINO-5-(HYDROXYMETHYL)CYCLOPENTANE-1,2-DIOL DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2005073213
Kind Code:
A3
Abstract:
The invention relates to a method for the production of acetals and ketals of 3-amino-5-(hydroxymethyl)cyclopentane-1,2-diols of formula (I) (and/or the enantiomer), where R = H, C1-6 alkyl, C3-8 cycloalkyl or benzyl and i) R<2> = methyl and R<3> = ethyl, ii) R<2> = H and R<3> = C1-6 alkyl or phenyl or iii) R<2> and R<3> together form a group of formula -(CH2)n- with n = 4 to 6, present as free amines or as salts of di- or tri-basic organic acids, starting from 2-acetyl-2-aza-bicyclo[2.2.1]hept-5-en-3-one of formula (II) (and/or the enantiomer). The method is equally useful, depending on the starting material, for the production of enantiomerically-pure compounds, or mixtures with arbitrary enantiomeric content.
Inventors:
GRIFFITHS GARETH-JOHN (CH)
LANGE SILVIA (CH)
BRIEDEN WALTER (CH)
LANGE SILVIA (CH)
BRIEDEN WALTER (CH)
Application Number:
PCT/EP2005/000643
Publication Date:
November 24, 2005
Filing Date:
January 24, 2005
Export Citation:
Assignee:
LONZA AG (CH)
GRIFFITHS GARETH-JOHN (CH)
LANGE SILVIA (CH)
BRIEDEN WALTER (CH)
GRIFFITHS GARETH-JOHN (CH)
LANGE SILVIA (CH)
BRIEDEN WALTER (CH)
International Classes:
C07D209/52; C07D317/44; C07D491/08; (IPC1-7): C07D317/44; C07D491/08; C07D209/52
Domestic Patent References:
| WO2002091988A2 | 2002-11-21 | |||
| WO2000023447A1 | 2000-04-27 | |||
| WO1997003053A1 | 1997-01-30 | |||
| WO2000003032A1 | 2000-01-20 |
Foreign References:
| US5684159A | 1997-11-04 |
Other References:
See also references of EP 1771434A2
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