Title:
METHOD FOR PRODUCTION OF LIMULUS-POSITIVE GLYCOLIPID, LIMULUS-POSITIVE GLYCOLIPID, AND LIMULUS-POSITIVE GLYCOLIPID BLEND
Document Type and Number:
WIPO Patent Application WO/2008/007476
Kind Code:
A1
Abstract:
Xanthan gum, which is derived from a Xanthomonas microorganism, has been commercially supplied and eaten for many years. It is now found that xanthan gum contains a limulus-positive glycolipid. The limulus-positive glycolipid is purified from xanthan gum, and it is found that the limulus-positive glycolipid has an immunostimulating effect. Disclosed is a method for production of a limulus-positive glycolipid containing an immunostimulating substance safely, at a low cost, and in a high concentration. The method is characterized by extracting a limulus-positive glycolipid from xanthan gum. A limulus-positive glycolipid blend containing the limulus-positive glycolipid can be used in various applications including pharmaceuticals, veterinary pharmaceuticals, quasi-drugs, cosmetics, foods, functional foods, feeding stuffs and bathwater additives.
Inventors:
SOMA GEN-ICHIRO (JP)
KOHCHI CHIE (JP)
INAGAWA HIROYUKI (JP)
NISHIZAWA TAKASHI (JP)
KOHCHI CHIE (JP)
INAGAWA HIROYUKI (JP)
NISHIZAWA TAKASHI (JP)
Application Number:
PCT/JP2007/053742
Publication Date:
January 17, 2008
Filing Date:
February 28, 2007
Export Citation:
Assignee:
BIOMEDICAL RES GROUP INC (JP)
MACROPHI INC (JP)
SOMA GEN-ICHIRO (JP)
KOHCHI CHIE (JP)
INAGAWA HIROYUKI (JP)
NISHIZAWA TAKASHI (JP)
MACROPHI INC (JP)
SOMA GEN-ICHIRO (JP)
KOHCHI CHIE (JP)
INAGAWA HIROYUKI (JP)
NISHIZAWA TAKASHI (JP)
International Classes:
C08B37/00; A23K1/16; A23L1/30; A61K8/02; A61K8/60; A61K8/99; A61P37/04; A61Q19/10; C12P19/04; A61K35/74
Foreign References:
| JPS584724A | 1983-01-11 | |||
| JPH10506612A | 1998-06-30 | |||
| JPH06263650A | 1994-09-20 | |||
| JPH07187949A | 1995-07-25 | |||
| JP2006194965A | 2006-07-27 |
Other References:
IELPI L. ET AL.: "Lipid-linked intermediates in the biosynthesis of xanthan gum", FEBS LETTERS, vol. 130, no. 2, 3 August 1981 (1981-08-03), pages 253 - 256, XP003020495
MIYAKE K.: "Toll-yo Juyotai 4/MD-2 ni yoru Lipopolysaccharide-rui no Sentensei Men'eki Ninshiki Oyobi Endotoxin Shock ni Okeru Chiryo Kansho no Tame no Kotai ni yoru Sono Men'eki Ninshiki no Sosa", JAPANESE SOCIETY FOR IMMUNOLOGY SOKAI. GAKUJUTSU SHUKAI KIROKU, vol. 34, 5 November 2004 (2004-11-05), XP003020496
See also references of EP 2042520A4
CHIE KOHCHI ET AL.: "Innate Immunity Regulatory Action of Fermented Wheat Extract", NEW FOOD INDUSTRY, vol. 48, 2006, pages 19 - 27
ULMER, A. J. ET AL.: "Lipopolysaccharide: Structure, Bioactivity, Receptors, and Signal Transduction", TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, vol. 14, 2000, pages 53 - 68
STARNES, C. O.: "Coley's Toxins in Perspective", NATURE, vol. 357, 1992, pages LL-12
NISHIZAWA, T. ET AL., CHEM. PHARM. BULL., vol. 40, 1992, pages 479 - 483
HIROYUKI INAGAWA ET AL.: "Therapeutic and Preventive Effect of Lipopolysaccharide (LPSw) having Macrophage Activation Action and Derived from Wheat of Various Diseases", BIOTHERAPY, vol. 5, 1991, pages 617 - 621
KIYOSHI TAKEDA ET AL.: "Toll-like Receptors in Innate", INTERNATIONAL IMMUNOLOGY, vol. 17, pages 1 - 14
"SeikagakuJiten", 1990, pages: 1949
MIYAKE K.: "Toll-yo Juyotai 4/MD-2 ni yoru Lipopolysaccharide-rui no Sentensei Men'eki Ninshiki Oyobi Endotoxin Shock ni Okeru Chiryo Kansho no Tame no Kotai ni yoru Sono Men'eki Ninshiki no Sosa", JAPANESE SOCIETY FOR IMMUNOLOGY SOKAI. GAKUJUTSU SHUKAI KIROKU, vol. 34, 5 November 2004 (2004-11-05), XP003020496
See also references of EP 2042520A4
CHIE KOHCHI ET AL.: "Innate Immunity Regulatory Action of Fermented Wheat Extract", NEW FOOD INDUSTRY, vol. 48, 2006, pages 19 - 27
ULMER, A. J. ET AL.: "Lipopolysaccharide: Structure, Bioactivity, Receptors, and Signal Transduction", TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, vol. 14, 2000, pages 53 - 68
STARNES, C. O.: "Coley's Toxins in Perspective", NATURE, vol. 357, 1992, pages LL-12
NISHIZAWA, T. ET AL., CHEM. PHARM. BULL., vol. 40, 1992, pages 479 - 483
HIROYUKI INAGAWA ET AL.: "Therapeutic and Preventive Effect of Lipopolysaccharide (LPSw) having Macrophage Activation Action and Derived from Wheat of Various Diseases", BIOTHERAPY, vol. 5, 1991, pages 617 - 621
KIYOSHI TAKEDA ET AL.: "Toll-like Receptors in Innate", INTERNATIONAL IMMUNOLOGY, vol. 17, pages 1 - 14
"SeikagakuJiten", 1990, pages: 1949
Attorney, Agent or Firm:
NAKAMURA, Kazuo (Nakamura Bldg. 2F50-10, Nishikamata 7-chome,Ota-k, Tokyo 51, JP)
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