Title:
METHOD FOR THE PRODUCTION OF PRIMARY AMINES
Document Type and Number:
WIPO Patent Application WO/2014/041011
Kind Code:
A3
Abstract:
The present invention relates to a novel enzymatically catalyzed method for the production of aliphatic primary amines, which method comprises the enzymatic oxidation of a primary aliphatic alcohol catalyzed by an alcohol dehydrogenase, amination of the resulting oxocompound catalyzed by a transaminase and optionally coupled with an enzymatically catalyzed regeneration of the consumed cofactor; recombinant expression systems and microorganisms procuring the required enzyme activities; and bioreactors for performing such methods; as well as the use of the obtained amines in organic synthesis, in particular for preparing organic polymers.
Inventors:
BALDENIUS KAI-UWE (DE)
DITRICH KLAUS (DE)
BREUER MICHAEL (DE)
NAVICKAS VAIDOTAS (DE)
DICK JANSEN (NL)
BARTSCH SEBASTIAN (DE)
CRISMARU CIPRIAN GICA (RO)
DITRICH KLAUS (DE)
BREUER MICHAEL (DE)
NAVICKAS VAIDOTAS (DE)
DICK JANSEN (NL)
BARTSCH SEBASTIAN (DE)
CRISMARU CIPRIAN GICA (RO)
Application Number:
PCT/EP2013/068786
Publication Date:
May 08, 2014
Filing Date:
September 11, 2013
Export Citation:
Assignee:
BASF SE (DE)
BASF SCHWEIZ AG (CH)
UNIV GRONINGEN (NL)
BASF SCHWEIZ AG (CH)
UNIV GRONINGEN (NL)
International Classes:
C12P13/00; C12N9/04; C12N9/06; C12N9/10
Domestic Patent References:
| WO2013011018A1 | 2013-01-24 | |||
| WO2009077461A1 | 2009-06-25 |
Foreign References:
| DE102009000592A1 | 2010-08-05 |
Other References:
JOHANN H. SATTLER ET AL: "Redox Self-Sufficient Biocatalyst Network for the Amination of Primary Alcohols", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 51, no. 36, 3 September 2012 (2012-09-03), pages 9156 - 9159, XP055051110, ISSN: 1433-7851, DOI: 10.1002/anie.201204683
JOERG H SCHRITTWIESER ET AL: "Recent biocatalytic oxidationreduction cascades", CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 15, no. 2, April 2011 (2011-04-01), pages 249 - 256, XP028187359, ISSN: 1367-5931, [retrieved on 20101111], DOI: 10.1016/J.CBPA.2010.11.010
YUN H ET AL: "Simultaneous synthesis of enantiomerically pure (R)-1-phenylethanol and (R)-alpha-methylbenzylamine from racemic alpha-methylbenzylamine using omega-transaminase/alcohol dehydrogenase/glucose dehydrogenase coupling reaction", BIOTECHNOLOGY LETTERS, KEW, SURREY, GB, vol. 25, no. 10, 1 May 2003 (2003-05-01), pages 809 - 814, XP002420353, ISSN: 0141-5492, DOI: 10.1023/A:1023500406897
JOERG H SCHRITTWIESER ET AL: "Recent biocatalytic oxidationreduction cascades", CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 15, no. 2, April 2011 (2011-04-01), pages 249 - 256, XP028187359, ISSN: 1367-5931, [retrieved on 20101111], DOI: 10.1016/J.CBPA.2010.11.010
YUN H ET AL: "Simultaneous synthesis of enantiomerically pure (R)-1-phenylethanol and (R)-alpha-methylbenzylamine from racemic alpha-methylbenzylamine using omega-transaminase/alcohol dehydrogenase/glucose dehydrogenase coupling reaction", BIOTECHNOLOGY LETTERS, KEW, SURREY, GB, vol. 25, no. 10, 1 May 2003 (2003-05-01), pages 809 - 814, XP002420353, ISSN: 0141-5492, DOI: 10.1023/A:1023500406897
Attorney, Agent or Firm:
REITSTÖTTER KINZEBACH (München, DE)
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