Title:
METHOD FOR PROVIDING INFORMATION ON ANTIDEPRESSANT THERAPEUTIC EFFECT USING SINGLE NUCLEOTIDE POLYMORPHISM
Document Type and Number:
WIPO Patent Application WO/2010/114188
Kind Code:
A1
Abstract:
The present invention relates to a method for providing information for SSRIs antidepressant therapeutic effect by identifying TPH2 gene polymorphism rs4760815, SLC6A4 gene polymorphism 5-HTTLPR, SLC6A4 gene polymorphism rs2066713, GAD1 gene polymorphism rs3828275, and GRIK2 gene polymorphism rs543196. Thus, it is possible to screen antidepressants on the basis of genetic information, to detect exacerbation and recurrence of depressive symptoms in the early stages, to develop personalized medicines effectively, and to establish a personalized therapeutic model for depression which is suitable for Koreans. In addition, the domestic infrastructure of clinical trials is expanded and thus competitiveness in the pharmaceutical market is secured, and the technology for prediction of drugs can be occupied in advance.
Inventors:
KIM DOH KWAN (KR)
KIM JONG WON (KR)
KIM SEON WOO (KR)
CARROLL BERNARD J (US)
LIM SHINN WON (KR)
KIM JONG WON (KR)
KIM SEON WOO (KR)
CARROLL BERNARD J (US)
LIM SHINN WON (KR)
Application Number:
PCT/KR2009/002049
Publication Date:
October 07, 2010
Filing Date:
April 20, 2009
Export Citation:
Assignee:
SAMSUNGN LIFE WELFARE FOUNDATI (KR)
KIM DOH KWAN (KR)
KIM JONG WON (KR)
KIM SEON WOO (KR)
CARROLL BERNARD J (US)
LIM SHINN WON (KR)
KIM DOH KWAN (KR)
KIM JONG WON (KR)
KIM SEON WOO (KR)
CARROLL BERNARD J (US)
LIM SHINN WON (KR)
International Classes:
C12Q1/68
Foreign References:
| KR20080090132A | 2008-10-08 | |||
| US7122308B2 | 2006-10-17 | |||
| US20050069936A1 | 2005-03-31 | |||
| US20080233657A1 | 2008-09-25 |
Other References:
P. ZILL ET AL.: "SNP and haplotype analysis of a novel tryptophan hydroxylase isoform(TPH2) gene provide evidence for association with major depression.", MOLECULAR PSYCHIATRY, vol. 9, 2004, pages 1030 - 1036, XP002558940, DOI: doi:10.1038/sj.mp.4001525
JEFFREY B. KRAFT ET AL.: "Analysis of Association Between the Serotonin Transporter and Antidepressant Response in a Large Clinical Sample.", BIOL PSYCHIATRY, vol. 61, 2007, pages 734 - 742, XP005912737, DOI: doi:10.1016/j.biopsych.2006.07.017
HYERAN KIM ET AL.: "Monoamine Transporter Gene Polymorphisms and Antidepressant Response in Koreans With Late-Life Depression.", JAMA, vol. 296, no. 13, 4 October 2006 (2006-10-04), pages 1609 - 1618
KEIZO YOSHIDA ET AL.: "Prediction of Antidepressant Response to Milnacipran by Norepinephrine Transporter Gene Polymorphisms.", AM J PSYCHIATRY, vol. 161, 2004, pages 1575 - 1580
JEFFREY B. KRAFT ET AL.: "Analysis of Association Between the Serotonin Transporter and Antidepressant Response in a Large Clinical Sample.", BIOL PSYCHIATRY, vol. 61, 2007, pages 734 - 742, XP005912737, DOI: doi:10.1016/j.biopsych.2006.07.017
HYERAN KIM ET AL.: "Monoamine Transporter Gene Polymorphisms and Antidepressant Response in Koreans With Late-Life Depression.", JAMA, vol. 296, no. 13, 4 October 2006 (2006-10-04), pages 1609 - 1618
KEIZO YOSHIDA ET AL.: "Prediction of Antidepressant Response to Milnacipran by Norepinephrine Transporter Gene Polymorphisms.", AM J PSYCHIATRY, vol. 161, 2004, pages 1575 - 1580
Attorney, Agent or Firm:
NAM, SANG-SUN (KR)
남상선 (KR)
남상선 (KR)
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