Title:
METHOD FOR PROVIDING INFORMATION ON DEPRESSION DIAGNOSIS USING RATE OF CATECHOLAMINE-O-METHYL TRANSFERASE GENE METHYLATION
Document Type and Number:
WIPO Patent Application WO/2019/017666
Kind Code:
A1
Abstract:
The present invention relates to a method for providing information on depression diagnosis using a rate of catecholamine-O-methyl transferase (COMT) gene methylation. The present invention contributes to neurophysiological evidence for stress-associated variation of dopaminergic neurotransmitters and can provide information on depression diagnosis.
Inventors:
HAM BYUNG JOO (KR)
Application Number:
PCT/KR2018/008035
Publication Date:
January 24, 2019
Filing Date:
July 16, 2018
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
C12Q1/6883; A61B5/16
Foreign References:
| KR20150131147A | 2015-11-24 | |||
| CN104655705A | 2015-05-27 | |||
| US20100304391A1 | 2010-12-02 |
Other References:
HOSANG, GEORGINA M. ET AL.: "Stressful Life Events and Catechol-O-methyl-transferase (COMT) Gene in Bipolar Disorder", DEPRESSION AND ANXIETY, vol. 34, no. 5, 19 January 2017 (2017-01-19), pages 419 - 426, XP055563240
WRAY, NAOMI R. ET AL.: "Association Study of Candidate Variants of COMT with Neuroticism, Anxiety and Depression", AMERICAN JOURNAL OF MEDICAL GENETICS PART B: NEUROPSYCHIATRIC GENETICS, vol. 147B, 2008, pages 1314 - 1318, XP055563244
NA, KYOUNG-SAE ET AL.: "Differential Effect of COMT Gene Methylation on the Prefrontal Connectivity in Subjects with Depression versus Healthy Subjects", NEUROPHARMACOLOGY, vol. 137, 30 April 2018 (2018-04-30), pages 57 - 70, XP055563249
WRAY, NAOMI R. ET AL.: "Association Study of Candidate Variants of COMT with Neuroticism, Anxiety and Depression", AMERICAN JOURNAL OF MEDICAL GENETICS PART B: NEUROPSYCHIATRIC GENETICS, vol. 147B, 2008, pages 1314 - 1318, XP055563244
NA, KYOUNG-SAE ET AL.: "Differential Effect of COMT Gene Methylation on the Prefrontal Connectivity in Subjects with Depression versus Healthy Subjects", NEUROPHARMACOLOGY, vol. 137, 30 April 2018 (2018-04-30), pages 57 - 70, XP055563249
Attorney, Agent or Firm:
DAHAI INTERNATIONAL PATENT & LAW FIRM (KR)
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