Title:
METHOD FOR PROVIDING INFORMATION FOR DISEASE DIAGNOSIS THROUGH DIR CONVERSION
Document Type and Number:
WIPO Patent Application WO/2024/096628
Kind Code:
A1
Abstract:
One aspect relates to a method which finds an index gene in the same genome as DEG and performs DEG-index-ratio (Dir) transformation using the index gene, so that RNA-seq data can be used to provide information for diagnosis of a disease. The method, according to one aspect, can control individual data variations in RNA-seq results through multidimensional Dir transformation and can be useful in providing information for early diagnosis of a disease.
Inventors:
OH HYUN WOO (KR)
SHIN SANG WOON (KR)
SHIN SANG WOON (KR)
Application Number:
PCT/KR2023/017410
Publication Date:
May 10, 2024
Filing Date:
November 02, 2023
Export Citation:
Assignee:
KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)
International Classes:
G16B20/00; G16B30/10; G16B50/00
Foreign References:
| CN114582425A | 2022-06-03 |
Other References:
J ZYPRYCH-WALCZAK: "The Impact of Normalization Methods on RNA-Seq Data Analysis", 15 June 2015 (2015-06-15), XP093154353, Retrieved from the Internet
K. D. HANSEN: "Removing technical variability in RNA-seq data using conditional quantile normalization", BIOSTATISTICS, OXFORD UNIVERSITY PRESS , OXFORD, GB, vol. 13, no. 2, 1 April 2012 (2012-04-01), GB , pages 204 - 216, XP093169107, ISSN: 1465-4644, DOI: 10.1093/biostatistics/kxr054
YINGDONG ZHAO: "TPM, FPKM, or Normalized Counts? A Comparative Study of Quantification Measures for the Analysis of RNA-seq Data from the NCI Patient-Derived Models Repository", JOURNAL OF TRANSLATIONAL MEDICINE, BIOMED CENTRAL, vol. 19, no. 1, 1 December 2021 (2021-12-01), XP093169110, ISSN: 1479-5876, DOI: 10.1186/s12967-021-02936-w
YOUPING DENG: "Ratio-Based Method To Identify True Biomarkers by Normalizing Circulating ncRNA Sequencing and Quantitative PCR Data", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 91, no. 10, 21 May 2019 (2019-05-21), US , pages 6746 - 6753, XP093169112, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.9b00821
K. D. HANSEN: "Removing technical variability in RNA-seq data using conditional quantile normalization", BIOSTATISTICS, OXFORD UNIVERSITY PRESS , OXFORD, GB, vol. 13, no. 2, 1 April 2012 (2012-04-01), GB , pages 204 - 216, XP093169107, ISSN: 1465-4644, DOI: 10.1093/biostatistics/kxr054
YINGDONG ZHAO: "TPM, FPKM, or Normalized Counts? A Comparative Study of Quantification Measures for the Analysis of RNA-seq Data from the NCI Patient-Derived Models Repository", JOURNAL OF TRANSLATIONAL MEDICINE, BIOMED CENTRAL, vol. 19, no. 1, 1 December 2021 (2021-12-01), XP093169110, ISSN: 1479-5876, DOI: 10.1186/s12967-021-02936-w
YOUPING DENG: "Ratio-Based Method To Identify True Biomarkers by Normalizing Circulating ncRNA Sequencing and Quantitative PCR Data", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 91, no. 10, 21 May 2019 (2019-05-21), US , pages 6746 - 6753, XP093169112, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.9b00821
Attorney, Agent or Firm:
THEWAVE IP LAW FIRM (KR)
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