Title:
METHOD OF PULMONARY ADMINISTRATION OF AN AGENT
Document Type and Number:
WIPO Patent Application WO2004110493
Kind Code:
A3
Abstract:
A method for administering a therapeutic or diagnostic agent to a subject is described. The method includes providing a suspension of liposomes comprised of one or more of vesicle-forming lipids selected from (i) a vesicle-forming lipid derivatized with a hydrophilic polymer and (ii) a neutral lipopolymer, said liposomes being associated with said therapeutic or diagnostic agent, forming an aerosol of said liposome suspension; and administering the aerosol to the subject by inhalation. The liposome formulation delivers intact liposomal particles to the respiratory tract of said subject to form a depot of therapeutic agent therein with no observable provocation of an immune response, as measured by neutrophil or macrophage cell count in the lung after administration.
Inventors:
WONG FRANCES M P (US)
DAS ANUK (US)
SEIDEMAN JONATHAN (US)
GUO LUKE (US)
HUANG ANTHONY (US)
DAS ANUK (US)
SEIDEMAN JONATHAN (US)
GUO LUKE (US)
HUANG ANTHONY (US)
Application Number:
PCT/US2004/016962
Publication Date:
September 15, 2005
Filing Date:
May 27, 2004
Export Citation:
Assignee:
ALZA CORP (US)
WONG FRANCES M P (US)
DAS ANUK (US)
SEIDEMAN JONATHAN (US)
GUO LUKE (US)
HUANG ANTHONY (US)
WONG FRANCES M P (US)
DAS ANUK (US)
SEIDEMAN JONATHAN (US)
GUO LUKE (US)
HUANG ANTHONY (US)
International Classes:
A61K9/00; A61K9/127; (IPC1-7): A61K9/127; A61K9/72
Domestic Patent References:
| WO2001039789A1 | 2001-06-07 |
Foreign References:
| CA2215716C | 1999-12-07 |
Other References:
KONDURI KAMESWARI S ET AL: "Efficacy of liposomal budesonide in experimental asthma.", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 111, no. 2, February 2003 (2003-02-01), pages 321 - 327, XP008047651, ISSN: 0091-6749
EASTMAN S J ET AL: "A CONCENTRATED AND STABLE AEROSOL FORMULATION OF CATIONIC LIPI:DNA COMPLEXES GIVING HIGH-LEVEL GENE EXPRESSION IN MOUSE LUNG", HUMAN GENE THERAPY, vol. 8, no. 6, 10 April 1997 (1997-04-10), pages 765 - 773, XP002035786, ISSN: 1043-0342
BAKKER-WOUDENBERG IRMA A J M ET AL: "Ciprofloxacin in polyethylene glycol-coated liposomes: Efficacy in rat models of acute or chronic Pseudomonas aeruginosa infection", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 46, no. 8, August 2002 (2002-08-01), pages 2575 - 2581, XP002329831, ISSN: 0066-4804
EASTMAN S J ET AL: "A CONCENTRATED AND STABLE AEROSOL FORMULATION OF CATIONIC LIPI:DNA COMPLEXES GIVING HIGH-LEVEL GENE EXPRESSION IN MOUSE LUNG", HUMAN GENE THERAPY, vol. 8, no. 6, 10 April 1997 (1997-04-10), pages 765 - 773, XP002035786, ISSN: 1043-0342
BAKKER-WOUDENBERG IRMA A J M ET AL: "Ciprofloxacin in polyethylene glycol-coated liposomes: Efficacy in rat models of acute or chronic Pseudomonas aeruginosa infection", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 46, no. 8, August 2002 (2002-08-01), pages 2575 - 2581, XP002329831, ISSN: 0066-4804
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