Title:
METHOD FOR PURIFYING ANSAMITOCIN P-3
Document Type and Number:
WIPO Patent Application WO/2022/262591
Kind Code:
A1
Abstract:
A method for purifying ansamitocin P-3, comprising using a resin to adsorb an ansamitocin fermentation solution, using an organic solvent for resolution, collecting and concentrating a resolution solution, subjecting the resolution solution to reverse phase filler high-pressure preparation to obtain a chromatography solution, and obtaining a target product by means of simple crystallization and precipitation. Quality control of the purification process conforms to the GMP standard, and the process is low in cost and suitable for industrial application. The ansamitocin P-3 purified by using the method as provided can stably achieve purity levels of 95% or higher.
Inventors:
CHEN FUCHEN (CN)
ZHOU CHENFENG (CN)
DU MINGJING (CN)
XU HUANPU (CN)
LIAO SHOUYA (CN)
ZHOU CHENFENG (CN)
DU MINGJING (CN)
XU HUANPU (CN)
LIAO SHOUYA (CN)
Application Number:
PCT/CN2022/096856
Publication Date:
December 22, 2022
Filing Date:
June 02, 2022
Export Citation:
Assignee:
HANGZHOU ZHONGMEIHUADONG PHARMACEUTICAL CO LTD (CN)
International Classes:
C12P17/18; C07D498/18; C12N1/20; C12R1/01
Foreign References:
| CN104745655A | 2015-07-01 | |||
| CN107778358A | 2018-03-09 | |||
| CN104877929A | 2015-09-02 | |||
| US20070135629A1 | 2007-06-14 | |||
| US20020015984A1 | 2002-02-07 |
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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