METHOD FOR PURIFYING COMPOSITION

Title:

METHOD FOR PURIFYING COMPOSITION

Document Type and Number:

WIPO Patent Application WO/2023/112939

Kind Code:

A1

Abstract:

A method for purifying a composition that comprises a step for dissolving the composition containing a compound represented by formula(1) [in formula (1): R1 represents -N(R2)-R2 (wherein R2 represents a C1-C4 alkyl group); R3 and R4 represent a C3-C8 alkanediyl group; R5 represents a hydroxyl group; R6 represents -R7-OH (wherein R7 represents a C4-C12 alkanediyl group) or a hydrogen atom; and n is an integer of 0 or 1] in an aqueous layer and performing liquid-liquid extraction, wherein an oil layer used in the liquid-liquid extraction contains one or more liquids selected from the group consisting of a ketone liquid, an ester liquid and an ether liquid each having a solubility parameter (SP value) of 14.8-20.5 (MPa1/2).

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Inventors:

MIYAZAKI YUTA (JP)
ARAI TAKAYUKI (JP)
ITO MASAYOSHI (JP)
NEGISHI HASHIRU (JP)
HARASHIMA HIDEYOSHI (JP)
SATO YUSUKE (JP)

Application Number:

PCT/JP2022/045954

Publication Date:

June 22, 2023

Filing Date:

December 14, 2022

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Assignee:

JSR CORP (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)

International Classes:

C07C213/10; A61K9/16; A61K31/713; A61K47/18; A61K47/24; A61K47/28; A61K47/34; A61P35/00; C07C219/06; C07C219/08; C07C227/40; C07C229/12; C12N15/113

Domestic Patent References:

WO2018230710A1	2018-12-20
WO2021113365A1	2021-06-10
WO2019027055A1	2019-02-07
WO2016153012A1	2016-09-29

Foreign References:

JP2019151589A	2019-09-12
EP3443952A1	2019-02-20
JPH03204594A	1991-09-06
US20170273905A1	2017-09-28

Other References:

WARASHINA S. ET AL.: "A lipid nanoparticle for the efficient delivery of siRNA to dendritic cells", JOURNAL OF CONTROLLED RELEASE, vol. 225, 2016, pages 183 - 191, XP029438895, DOI: 10.1016/j.jconrel.2016.01.042
"Institutional Animal Care and Use Committee", HOKKAIDO UNIVERSITY

Attorney, Agent or Firm:

MATSUNUMA Yasushi et al. (JP)

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