Title:
METHOD FOR PURIFYING LEVETIRACETAM INTERMEDIATE
Document Type and Number:
WIPO Patent Application WO/2023/178538
Kind Code:
A1
Abstract:
The present invention relates to the field of pharmaceutical chemical engineering, in particular to a method for purifying a levetiracetam intermediate, which comprises the following steps: (1) hydrolyzing and acidifying a crude product of a compound of formula III and performing crystallization to obtain a compound of formula IV; and (2) subjecting the compound of formula IV to an esterification reaction and separation to obtain a purified compound of formula III. The present method has a purification effect obviously superior to that of a physical purification mode, can reach a total yield of 90% or above, and has s great practical value.
Inventors:
YAN FENGFENG (CN)
CHEN HUI (CN)
GONG YULONG (CN)
ZHU YUANXUN (CN)
CHEN HUI (CN)
GONG YULONG (CN)
ZHU YUANXUN (CN)
Application Number:
PCT/CN2022/082401
Publication Date:
September 28, 2023
Filing Date:
March 23, 2022
Export Citation:
Assignee:
ZHEJIANG HUAHAI PHARM CO LTD (CN)
International Classes:
C07B41/08; C07D207/27; C07B41/12; C07B63/02
Foreign References:
| US4470988A | 1984-09-11 | |||
| CN101511786A | 2009-08-19 | |||
| CN110590635A | 2019-12-20 | |||
| CN113861090A | 2021-12-31 |
Other References:
JAMSHED H. SHAH, GLENN M. SWARTZ, ADONIA E. PAPATHANASSIU, ANTHONY M. TRESTON, WILLIAM E. FOGLER, JOHN W. MADSEN, SHAWN J. GREEN: "Synthesis and Enantiomeric Separation of 2-Phthalimidino-glutaric Acid Analogues: Potent Inhibitors of Tumor Metastasis", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 42, no. 16, 1 August 1999 (1999-08-01), pages 3014 - 3017, XP055079607, ISSN: 00222623, DOI: 10.1021/jm990083y
Attorney, Agent or Firm:
HANGZHOU HANGCHENG PATENT ATTORNEY OFFICE CO., LTD. (CN)
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