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Title:
METHOD FOR PURIFYING PURE THIOFLAVIN T, METHOD FOR PRODUCING PURE THIOFLAVIN T, COMPOSITION INCLUDING THIOFLAVIN T, AND AMYLOID DETECTION METHOD
Document Type and Number:
WIPO Patent Application WO/2017/056758
Kind Code:
A1
Abstract:
The present invention relates to a method for purifying pure thioflavin T, said method being provided with: a step for preparing a thioflavin T solution obtained by dissolving crude thioflavin T in a polar solvent; a step in which the thioflavin T solution is brought into contact with a non-polar polymeric porous body; and a step in which the thioflavin T solution, having been brought into contact with the non-polar polymeric porous body, is separated from the non-polar polymeric porous body.

Inventors:
ODA AKINORI (JP)
SATOZONO HIROSHI (JP)
SHINKE TOMOMI (JP)
TAKATA YOHEI (JP)
Application Number:
PCT/JP2016/073846
Publication Date:
April 06, 2017
Filing Date:
August 15, 2016
Export Citation:
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Assignee:
HAMAMATSU PHOTONICS KK (JP)
International Classes:
C07D277/66; G01N33/52; G01N33/68
Domestic Patent References:
WO2008003943A22008-01-10
WO2006089221A22006-08-24
Foreign References:
JP2000198781A2000-07-18
US5486460A1996-01-23
Other References:
HSU, J.C.C. ET AL.: "Thioflavin T and Its Photoirradiative Derivatives: Exploring Their Spectroscopic Properties in the Absence and Presence of Amyloid Fibrils", THE JOURNAL OF PHYSICAL CHEMISTRY B, vol. 117, 2013, pages 3459 - 68, XP055370727
VOROPAI, E.S. ET AL.: "Spectral Properties of Thioflavin T and Its Complexes with Amyloid Fibrils", JOURNAL OF APPLIED SPECTROSCOPY, vol. 70, no. 6, 2003, pages 868 - 74, XP008146319
KAGAKU BINRAN, OYO KAGAKU HEN, 2003, pages 182 - 183
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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