Title:
METHOD FOR PURIFYING SUCRALOSE-6-ESTER
Document Type and Number:
WIPO Patent Application WO/2023/279276
Kind Code:
A1
Abstract:
The present application provides a method for purifying sucralose-6-ester. The method comprises: adding an oxidizing agent to a mother solution to be purified, carrying out an oxidation reaction under a first preset condition, then adding an alkaline hydrolysis agent thereto, and carrying out an alkaline hydrolysis reaction under a second preset condition to convert a target impurity into sucralose-6-ester so as to obtain an oxidized alkaline hydrolysis reaction solution; adjusting the pH value of the oxidized alkaline hydrolysis reaction solution to be neutral, keeping same for a period of time, then heating and filtering same to remove insoluble impurities, and then carrying out liquid separation to obtain a first aqueous phase and a first organic phase; extracting the first aqueous phase by using an extracting agent, and combining a second organic phase, which is obtained by means of the extraction, with the first organic phase to obtain a mother solution to be crystallized; and a step of crystallization, involving: concentrating the mother solution to be crystallized, and carrying out crystallization under a third preset condition to obtain a crude product of sucralose-6-ester and a first filtrate. By means of the present application, the yield of a target product is greatly improved while the impurity content is effectively removed.
Inventors:
ZHANG ZHENGSONG (CN)
SHEN DONGDONG (CN)
CI HAO (CN)
QIU XIN (CN)
SHEN DONGDONG (CN)
CI HAO (CN)
QIU XIN (CN)
Application Number:
PCT/CN2021/104937
Publication Date:
January 12, 2023
Filing Date:
July 07, 2021
Export Citation:
Assignee:
ANHUI JINHE IND CO LTD (CN)
International Classes:
C07H5/02; C07H1/00
Foreign References:
| CN109467578A | 2019-03-15 | |||
| CN110372764A | 2019-10-25 | |||
| CN112744945A | 2021-05-04 |
Other References:
WANG CHENGJIN; MOORE NATHAN; BIRCHER KEITH; ANDREWS SUSAN; HOFMANN RON: "Full-scale comparison of UV/H2O2 and UV/Cl2 advanced oxidation: The degradation of micropollutant surrogates and the formation of disinfection byproducts", WATER RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 161, 15 September 2019 (2019-09-15), AMSTERDAM, NL, pages 448 - 458, XP085733339, ISSN: 0043-1354, DOI: 10.1016/j.watres.2019.06.033
Attorney, Agent or Firm:
BEIJING LONGAN LAW FIRM (CN)
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