Title:
METHOD FOR PURIFYING SUCRALOSE-6-ETHYL ESTER
Document Type and Number:
WIPO Patent Application WO/2022/233040
Kind Code:
A1
Abstract:
Disclosed in the present invention is a method for purifying sucralose-6-ethyl ester, the method comprising: a second instance of boiling with water step, involving: taking a sucralose-6-ethyl ester mother solution, which has been subjected to boiling with water and a negative pressure treatment, adding a predetermined proportion of water to the sucralose-6-ethyl ester mother solution, thoroughly stirring and heating same for boiling same with water, and after stirring and boiling same with water for a preset time, carrying out solid-liquid separation to obtain a twice-water-boiled mother solution in which sucralose-6-ethyl ester is dissolved; a phase separation and extraction step, involving: leaving the twice-water-boiled mother solution to stand for phase separation, taking the separated upper phase, extracting same by using an alkane extraction agent at a preset temperature, and removing residual white oil in the upper phase; a recrystallization purification step, involving: evaporating a lower-layer effluent obtained from extraction, so as to obtain a solid, and purifying the solid by means of recrystallization to obtain sucralose-6-ethyl ester; and a recovering and recycling step: separating the extracted upper-layer effluent, recovering the alkane extraction agent, and recycling the alkane extraction agent for use in the phase separation and extraction step. The method is simple, efficient and low cost, and can effectively remove trace white oil and improve the purity of sucralose-6-ethyl ester.
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Inventors:
ZHENG XUELIAN (CN)
WANG DONG (CN)
CHEN YONGLE (CN)
WANG DONG (CN)
CHEN YONGLE (CN)
Application Number:
PCT/CN2021/092168
Publication Date:
November 10, 2022
Filing Date:
May 07, 2021
Export Citation:
Assignee:
ANHUI JINHE IND CO LTD (CN)
International Classes:
C07H13/04; C07H1/06
Domestic Patent References:
| WO2009137192A2 | 2009-11-12 |
Foreign References:
| CN109180748A | 2019-01-11 | |||
| CN112638924A | 2021-04-09 | |||
| CN109776627A | 2019-05-21 | |||
| CN109180748A | 2019-01-11 | |||
| CN101328195A | 2008-12-24 | |||
| CN101709069A | 2010-05-19 |
Other References:
See also references of EP 4335857A4
Attorney, Agent or Firm:
BEIJING LONGAN LAW FIRM (CN)
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