Title:
METHOD FOR PURIFYING VIRUS OR VIRUS-LIKE PARTICLE
Document Type and Number:
WIPO Patent Application WO/2021/002257
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method whereby a virus or a virus-like particle can be easily purified. The method according to the present invention for purifying a virus or a virus-like particle is characterized by comprising a step for contacting a liquid that contains the virus or virus-like particle with a water-insoluble inorganic compound that contains one or more elements selected from among magnesium, calcium and aluminum.
Inventors:
NISHIHACHIJYO MASAKATSU (JP)
SUEOKA TAKUMA (JP)
YAURA HISAKO (JP)
SUEOKA TAKUMA (JP)
YAURA HISAKO (JP)
Application Number:
PCT/JP2020/024804
Publication Date:
January 07, 2021
Filing Date:
June 24, 2020
Export Citation:
Assignee:
KANEKA CORP (JP)
International Classes:
C07K1/14; C12N7/02
Domestic Patent References:
| WO2003104413A2 | 2003-12-18 | |||
| WO2015111606A1 | 2015-07-30 | |||
| WO2018088519A1 | 2018-05-17 |
Foreign References:
| JPH11511326A | 1999-10-05 | |||
| JP2010530734A | 2010-09-16 | |||
| JP2000262280A | 2000-09-26 | |||
| DE2212909A1 | 1973-09-27 | |||
| JP2009039656A | 2009-02-26 | |||
| US20060281075A1 | 2006-12-14 | |||
| JP2017055766A | 2017-03-23 | |||
| JP2009042074A | 2009-02-26 | |||
| JP2017055766A | 2017-03-23 | |||
| JP2008137827A | 2008-06-19 | |||
| JP2019125243A | 2019-07-25 |
Other References:
MCLEAN, G.D. ET AL.: "Purification of Lettuce Necrotic Yellows Virus by Column Chromatography on Calcium Phosphate Gel", VIROLOGY, vol. 31, 1967, pages 585 - 591, XP023058138, DOI: 10.1016/0042-6822(67)90186-9
TOVARNIZKY, V.I. ET AL.: "Purification and concentration of influenza virus", DOKLADY AKADEMII NAUK SSSR, vol. 42, 1944, pages 194 - 195, XP009532283, ISSN: 0002-3264
SABIN, A.B.: "Experiments on the purification and concentration of the virus of Poliomyelitis", J. EXP. MED., vol. 56, 1932, pages 307 - 317, XP055783366
FARRAH, S.R. ET AL.: "Adsorption of Viruses by Diatomaceous Earth Coated with Metallic Oxides and Metaric Peroxides , Wat. Sci. Tech.", MATERIALS AND METHODS 2 3 237 RESULTS, vol. 24, no. 2, 1991, pages 235 - 240, XP008100133
THOMSSEN, R. ET AL.: "Different Pattern of Elution of Poliovirus Strains from DEAE-cellulose and Aluminium Hydroxide Gel", ARCH. GES. VIRUSFORSCH., vol. 15, no. 5, 1965, pages 735 - 738, XP055783372
CORBETT, M.K.: "Purification of Potato Virus X without aggregation", VIROLOGY, vol. 15, 1961, pages 8 - 15, XP023053100, DOI: 10.1016/0042-6822(61)90070-8
CHAHAL, P.S. ET AL.: "Primary recovery and chromatographic purification of adeno-associated virus type 2 produced by baculovirus/insect cell system", J. VIROL. METHODS, vol. 139, 2007, pages 61 - 70, XP005794347, DOI: 10.1016/j.jviromet.2006.09.011
CHAHAL, P.S. ET AL.: "Production of adeno-associated virus (AAV) serotypes by transient transfection of HEK293 cell suspension cultures for gene delivery", J. VIROL. METHODS, vol. 196, 2014, pages 163 - 173, XP055685164, DOI: 10.1016/j.jviromet.2013.10.038
NESTOLA, P. ET AL.: "Improved Virus Purification Processes for Vaccines and Gene Therapy", BIOTECHNOL. BIOENG., vol. 112, 2015, pages 843 - 857, XP055265059, DOI: 10.1002/bit.25545
KENICHI SAKAMOTO: "Alumina hydrate and alumina", LIGHT METALS, vol. 22, no. 4, 30 November 1971 (1971-11-30), JP , pages 295 - 308, XP009532290, ISSN: 0451-5994, DOI: 10.2464/jilm.22.295
SATO, TAICHI: "Aluminium Hydroxides and Aluminas", MINERALOGY JOURNAL, vol. 19, no. 1, 30 November 1988 (1988-11-30), JP, pages 21 - 41, XP009532289, ISSN: 1883-7018, DOI: 10.2465/gkk1952.19.21
KATO, A. ET AL.: "Preparation of Finely-Divided Alumina by Vapor Phase Reaction between Aluminum Chloride and Oxidizing Gases, and its Properties", JOURNAL OF THE SOCIETY OF MATERIALS SCIENCE, vol. 21, no. 225, 1972, pages 540 - 543, XP055783380
J. PHRAMA. BIOMED. ANAL., vol. 100, 2014, pages 145 - 149
"GenBank", Database accession no. ACQ43955.1
See also references of EP 3995504A4
TOVARNIZKY, V.I. ET AL.: "Purification and concentration of influenza virus", DOKLADY AKADEMII NAUK SSSR, vol. 42, 1944, pages 194 - 195, XP009532283, ISSN: 0002-3264
SABIN, A.B.: "Experiments on the purification and concentration of the virus of Poliomyelitis", J. EXP. MED., vol. 56, 1932, pages 307 - 317, XP055783366
FARRAH, S.R. ET AL.: "Adsorption of Viruses by Diatomaceous Earth Coated with Metallic Oxides and Metaric Peroxides , Wat. Sci. Tech.", MATERIALS AND METHODS 2 3 237 RESULTS, vol. 24, no. 2, 1991, pages 235 - 240, XP008100133
THOMSSEN, R. ET AL.: "Different Pattern of Elution of Poliovirus Strains from DEAE-cellulose and Aluminium Hydroxide Gel", ARCH. GES. VIRUSFORSCH., vol. 15, no. 5, 1965, pages 735 - 738, XP055783372
CORBETT, M.K.: "Purification of Potato Virus X without aggregation", VIROLOGY, vol. 15, 1961, pages 8 - 15, XP023053100, DOI: 10.1016/0042-6822(61)90070-8
CHAHAL, P.S. ET AL.: "Primary recovery and chromatographic purification of adeno-associated virus type 2 produced by baculovirus/insect cell system", J. VIROL. METHODS, vol. 139, 2007, pages 61 - 70, XP005794347, DOI: 10.1016/j.jviromet.2006.09.011
CHAHAL, P.S. ET AL.: "Production of adeno-associated virus (AAV) serotypes by transient transfection of HEK293 cell suspension cultures for gene delivery", J. VIROL. METHODS, vol. 196, 2014, pages 163 - 173, XP055685164, DOI: 10.1016/j.jviromet.2013.10.038
NESTOLA, P. ET AL.: "Improved Virus Purification Processes for Vaccines and Gene Therapy", BIOTECHNOL. BIOENG., vol. 112, 2015, pages 843 - 857, XP055265059, DOI: 10.1002/bit.25545
KENICHI SAKAMOTO: "Alumina hydrate and alumina", LIGHT METALS, vol. 22, no. 4, 30 November 1971 (1971-11-30), JP , pages 295 - 308, XP009532290, ISSN: 0451-5994, DOI: 10.2464/jilm.22.295
SATO, TAICHI: "Aluminium Hydroxides and Aluminas", MINERALOGY JOURNAL, vol. 19, no. 1, 30 November 1988 (1988-11-30), JP, pages 21 - 41, XP009532289, ISSN: 1883-7018, DOI: 10.2465/gkk1952.19.21
KATO, A. ET AL.: "Preparation of Finely-Divided Alumina by Vapor Phase Reaction between Aluminum Chloride and Oxidizing Gases, and its Properties", JOURNAL OF THE SOCIETY OF MATERIALS SCIENCE, vol. 21, no. 225, 1972, pages 540 - 543, XP055783380
J. PHRAMA. BIOMED. ANAL., vol. 100, 2014, pages 145 - 149
"GenBank", Database accession no. ACQ43955.1
See also references of EP 3995504A4
Attorney, Agent or Firm:
USFI PATENT ATTORNEYS INTERNATIONAL OFFICE (JP)
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