Title:
METHOD FOR REDUCING PYROGENIC ACTIVITY OF INACTIVATED WHOLE INFLUENZA VIRUS PARTICLE VACCINES
Document Type and Number:
WIPO Patent Application WO/2024/019113
Kind Code:
A1
Abstract:
Provided, with respect to the production of inactivated whole influenza virus particle vaccines using the embryonated chicken egg method, is a method for reducing pyrogenic activity. With respect to the method for producing an inactivated whole influenza virus particle vaccine using the embryonated chicken egg method, there is provided a method for reducing the pyrogenic activity of this vaccine, comprising a step for reducing the content of avian-derived microRNA in the virus solution containing whole influenza virus particles that is recovered from the embryonated chicken egg.
Inventors:
GOTANDA TAKUMA (JP)
MITSUMATA RYOTARO (JP)
MITSUMATA RYOTARO (JP)
Application Number:
PCT/JP2023/026580
Publication Date:
January 25, 2024
Filing Date:
July 20, 2023
Export Citation:
Assignee:
DENKA COMPANY LTD (JP)
International Classes:
A61K39/145; A61P31/16; C12Q1/68; C12Q1/70; G01N33/53
Domestic Patent References:
| WO2020067301A1 | 2020-04-02 |
Other References:
五反田卓摩ほか, 不活化全粒子ワクチンの鳥類ｍｉＲＮＡはワクチンの発熱活性に関与する, 第２６回日本ワクチン学会学術集会プログラム・抄録集, November 2022, p. 133 (2-2-11)
NEMATBAKHSH SARA, PEI PEI CHONG, SELAMAT JINAP, NORDIN NOORDIANA, IDRIS LOKMAN HAKIM, ABDULL RAZIS AHMAD FAIZAL: "Molecular Regulation of Lipogenesis, Adipogenesis and Fat Deposition in Chicken", GENES, MDPI AG, US, vol. 12, no. 3, 13 March 2021 (2021-03-13), US , pages 414, XP093130495, ISSN: 2073-4425, DOI: 10.3390/genes12030414
"Influenza Virus ", 1 January 2018, SPRINGER NEW YORK, New York, NY, ISBN: 978-1-4939-8678-1, article HUTCHINSON EDWARD C., STEGMANN MONIKA: "Chapter 5: Purification and Proteomics of Influenza Virions ", pages: 89 - 120, XP009552040, DOI: 10.1007/978-1-4939-8678-1_5
NEMATBAKHSH SARA, PEI PEI CHONG, SELAMAT JINAP, NORDIN NOORDIANA, IDRIS LOKMAN HAKIM, ABDULL RAZIS AHMAD FAIZAL: "Molecular Regulation of Lipogenesis, Adipogenesis and Fat Deposition in Chicken", GENES, MDPI AG, US, vol. 12, no. 3, 13 March 2021 (2021-03-13), US , pages 414, XP093130495, ISSN: 2073-4425, DOI: 10.3390/genes12030414
"Influenza Virus ", 1 January 2018, SPRINGER NEW YORK, New York, NY, ISBN: 978-1-4939-8678-1, article HUTCHINSON EDWARD C., STEGMANN MONIKA: "Chapter 5: Purification and Proteomics of Influenza Virions ", pages: 89 - 120, XP009552040, DOI: 10.1007/978-1-4939-8678-1_5
Attorney, Agent or Firm:
ARUGA PATENT OFFICE (JP)
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