Title:
METHOD FOR REFINING LISINOPRIL HYDRIDE
Document Type and Number:
WIPO Patent Application WO/2017/097193
Kind Code:
A1
Abstract:
The present invention provides a method for refining a lisinopril hydride crude product by means of solvent crystallization. The method specifically comprises: adding ketones solvents into a crude product which contains lisinopril hydride (I), lisinopril isomer (II) and other impurities (such as impurities III, IV), dissolving by heating, cooling for crystallizing for the first time, selectively adding seed crystal, then cooling for crystallizing, culturing crystal, continuously cooling for crystallizing, and carrying out suction filtration to obtain the lisinopril hydride, the yield reaching 80%, and the purity reaching up to 97% or more and even reaching up to 98% or more. The method can separate and refine hydride in a lisinopril hydride crude product, and increases the refining yield of lisinopril hydride, thereby having obvious utilization value in industrial application.
Inventors:
HU JIAXING (CN)
HUANG WENFENG (CN)
TU GUOLIANG (CN)
LIN ENMIN (CN)
WANG ANYU (CN)
FANG YULING (CN)
HUANG WENFENG (CN)
TU GUOLIANG (CN)
LIN ENMIN (CN)
WANG ANYU (CN)
FANG YULING (CN)
Application Number:
PCT/CN2016/108814
Publication Date:
June 15, 2017
Filing Date:
December 07, 2016
Export Citation:
Assignee:
ZHEJIANG HUAHAI PHARMACEUTICALS CO LTD (CN)
International Classes:
C07C233/47; A61P9/12; C07C231/24; C07K5/068
Foreign References:
| CN105439892A | 2016-03-30 | |||
| EP1405845A1 | 2004-04-07 | |||
| CN101239923A | 2008-08-13 | |||
| CN101973904A | 2011-02-16 |
Attorney, Agent or Firm:
BOSS&YOUNG PATENT AND TRADEMARK LAW OFFICE (CN)
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