A METHOD FOR REGULATING IMMUNE FUNCTION IN PRIMATES USING THE FOXP3 PROTEIN

Title:

A METHOD FOR REGULATING IMMUNE FUNCTION IN PRIMATES USING THE FOXP3 PROTEIN

Document Type and Number:

WIPO Patent Application WO2002090600

Kind Code:

A3

Abstract:

Isolated nucleic acid molecules are provided which encode Fkh, as well as mutant forms thereof. Also provided are expression vectors suitable for expressing such nucleic acid molecules, and host cells containing such expression vectors. Also provided are pharmaceutical compounds and methods of identifying such compounds that can modulate the immune system. In addition are provided methods for identifying proteins regulated by Scurfin and proteins that induce or inhibit Foxp3 expression.

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Inventors:

KHATTRI ROLI (US)
BRUNKOW MARY E (US)
RAMSDELL FRED (US)

Application Number:

PCT/US2002/015897

Publication Date:

June 10, 2004

Filing Date:

May 08, 2002

Export Citation:

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Assignee:

DARWIN MOLECULAR CORP (US)
CELLTECH R & D INC (US)
KHATTRI ROLI (US)
BRUNKOW MARY E (US)
RAMSDELL FRED (US)

International Classes:

C12N15/09; A61K35/76; A61K45/00; A61K48/00; A61P1/04; A61P3/10; A61P11/06; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P31/18; A61P35/00; C07K14/47; C12Q1/66; C12Q1/68; G01N33/50; A61K38/00; (IPC1-7): C12Q1/68; C12Q1/02; C07K16/00; C07K17/00; A61K38/00; A61K39/395; C07H21/04; A01K43/04

Domestic Patent References:

WO2000009693A2

2000-02-24

Other References: