Title:
METHOD FOR REMOVING VIRUSES IN PROTEIN SOLUTION
Document Type and Number:
WIPO Patent Application WO/2022/085606
Kind Code:
A9
Abstract:
Provided is a method for deactivating or removing viruses in a protein solution, the method including a step in which radiation treatment and virus removal membrane treatment or SD treatment are integrated and the conditions of these treatments are optimized to be mutually complementary. More specifically, the method includes: (a) a step in which a protein solution is treated by being irradiated with radiation so that the removal coefficient (LRV) for viruses with a virus particle diameter of less than 33 nm in the protein solution is at least 1.00; and (b1) a step in which viruses are removed from the treated protein solution by a virus removal membrane with an LRV of at least 4.00 for bacteriophage PP7, or (b2) a step in which the treated protein solution is brought into contact with a liquid mixture (SD liquid mixture) of an organic solvent and a surfactant and viruses are deactivated by organic solvent/surfactant treatment (SD treatment) so that the LRV for envelope viruses in the protein solution is at least 2.00. Also provided is a method for manufacturing a protein solution in/from which viruses have been deactivated/removed, the method including the abovementioned steps.
Inventors:
YUNOKI MIKIHIRO (JP)
URAYAMA TAKERU (JP)
URAYAMA TAKERU (JP)
Application Number:
PCT/JP2021/038339
Publication Date:
March 23, 2023
Filing Date:
October 18, 2021
Export Citation:
Assignee:
JAPAN BLOOD PRODUCTS ORGANIZATION (JP)
International Classes:
C12N7/04; C07K1/36
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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