Title:
METHOD FOR SALT-FREE PRODUCTION OF GAMMA-AMINOBUTYRIC ACID BY BIOTRANSFORMATION PROCESS
Document Type and Number:
WIPO Patent Application WO/2012/121456
Kind Code:
A1
Abstract:
The present invention relates to a method for producing γ-aminobutyric acid (GABA) by a biotransformation process using glutamate or glutamic acid as a substrate. According to the present invention, by adding, during a reaction, a solid acid which does not dissolve in a reaction medium, so as to match the pH appropriate for the activation of an enzyme, glutamate decarboxylase, γ-aminobutyric acid is effectively produced without generating salt, whereas salt generation is a problem with conventional pH control agents. As the solid acid can easily be removed through filtering or centrifugation after a reaction, the conventional complicated salt-removing process is obviated by the present invention. Therefore, the purification process is simplified and a more economical and effective production of γ-aminobutyric acid is possible.
Inventors:
WON KEEHOON (KR)
DINH THU HUONG (KR)
KANG TAEK JIN (KR)
DINH THU HUONG (KR)
KANG TAEK JIN (KR)
Application Number:
PCT/KR2011/005134
Publication Date:
September 13, 2012
Filing Date:
July 13, 2011
Export Citation:
Assignee:
UNIV DONGGUK IND ACAD COOP (KR)
KOREA HEALTH INDUSTRY DEV INST (KR)
WON KEEHOON (KR)
DINH THU HUONG (KR)
KANG TAEK JIN (KR)
KOREA HEALTH INDUSTRY DEV INST (KR)
WON KEEHOON (KR)
DINH THU HUONG (KR)
KANG TAEK JIN (KR)
International Classes:
C12P7/52; C12N9/88; C12P13/00
Foreign References:
| KR100857215B1 | 2008-09-05 | |||
| KR100923248B1 | 2009-10-27 | |||
| KR20090029723A | 2009-03-23 | |||
| JP2000279108A | 2000-10-10 |
Attorney, Agent or Firm:
BAE, KIM & LEE IP GROUP (KR)
특허법인 태평양 (KR)
특허법인 태평양 (KR)
Download PDF:
Claims: